D9 Drug design. Daniel Brown. D9.1 Discuss the use of a compound library in drug design. Traditionally, a large collection of related compounds are synthesized individually and evaluated for biological properties. However t his is time consuming and expensive.
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a large number of different compounds and
screen them for biological activity, resulting in
a “combinatorial library”. Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules or materials.
D9.4 Discuss how the polarity of a molecule can be modified to increase its aqueous solubility and how this facilitates its distribution around the body.
Taxol to increase its aqueous solubility and how this facilitates its distribution around the body. (Paclitaxel)