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Lecture 25

Lecture 25. QUESTIONS? Text 37607 Msg : 118916 Question. QUESTIONS? Goto http://pollev.com/ucibio Enter question. Last class. Nucleotide metabolism highlights. Metabolism overview. The future. Disease phenotype  treatment. Drug design & development. Protein engineering.

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Lecture 25

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  1. Lecture 25 QUESTIONS? Text 37607 Msg: 118916 Question QUESTIONS? Gotohttp://pollev.com/ucibio Enter question

  2. Last class Nucleotide metabolism highlights Metabolism overview

  3. The future Disease phenotype  treatment Drug design & development Protein engineering Industrial applications Diagnostics

  4. Metabolic engineering Engineer a whole pathway? Large scale production? Biosynthesis: - Fuel - Nutraceuticals What else?!?!!

  5. Example of metabolic engineering Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908

  6. Example of metabolic engineering Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908

  7. Example of metabolic engineering Pps Pps* Pps# Control Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908

  8. -Omics = Metabolomics! ENTIRE collection of metabolites! “Metabolome”

  9. Metabolome & drugs Kaddurah-Daouk, Rima, Bruce S. Kristal, and Richard M. Weinshilboum. "Metabolomics: a global biochemical approach to drug response and disease." Annu. Rev. Pharmacol. Toxicol. 48 (2008): 653-683.

  10. Discovering diagnostic markers Kenny, Louise C., et al. "Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning." Metabolomics 1.3 (2005): 227-234.

  11. Differentiating disease conditions Kaddurah-Daouk, Rima, Bruce S. Kristal, and Richard M. Weinshilboum. "Metabolomics: a global biochemical approach to drug response and disease." Annu. Rev. Pharmacol. Toxicol. 48 (2008): 653-683.

  12. The Human Metabolome project

  13. Synthetic biology – “creating” life… “Build” a genome from scratch? What is “minimal” genome?

  14. …and beyond! Protein + metabolic engineering Any compound, any time! “Download” vaccine to personal biofactory?!

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