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CHMI 2227E Biochemistry I

CHMI 2227E Biochemistry I. Gene expression. Nature of the gene. Nature of the gene. Nature of the gene. Normal fly. Antennapedia mutation. What happens when gene expression is screwed-up?. Central dogma of molecular biology. Transcription factors. Promoter.

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CHMI 2227E Biochemistry I

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  1. CHMI 2227EBiochemistry I Gene expression CHMI 2227 - E.R. Gauthier, Ph.D.

  2. Nature of the gene CHMI 2227 - E.R. Gauthier, Ph.D.

  3. CHMI 2227 - E.R. Gauthier, Ph.D.

  4. Nature of the gene CHMI 2227 - E.R. Gauthier, Ph.D.

  5. Nature of the gene CHMI 2227 - E.R. Gauthier, Ph.D.

  6. Normal fly Antennapedia mutation What happens when gene expression is screwed-up? CHMI 2227 - E.R. Gauthier, Ph.D.

  7. Central dogma of molecular biology CHMI 2227 - E.R. Gauthier, Ph.D.

  8. Transcription factors Promoter Transcription: turning on a gene CHMI 2227 - E.R. Gauthier, Ph.D.

  9. Promoters CHMI 2227 - E.R. Gauthier, Ph.D.

  10. Promoters CHMI 2227 - E.R. Gauthier, Ph.D.

  11. Transcription CHMI 2227 - E.R. Gauthier, Ph.D.

  12. Transcription Messenger RNA (mRNA) is antiparallel to template strand Complementarity (5’ 3’) CHMI 2227 - E.R. Gauthier, Ph.D.

  13. mRNAs are modified in eukaryotes CHMI 2227 - E.R. Gauthier, Ph.D.

  14. mRNAs are modified in eukaryotes CHMI 2227 - E.R. Gauthier, Ph.D.

  15. mRNAs are translated into proteins CHMI 2227 - E.R. Gauthier, Ph.D.

  16. Translation CHMI 2227 - E.R. Gauthier, Ph.D.

  17. Transfer RNA (tRNA) CHMI 2227 - E.R. Gauthier, Ph.D.

  18. 3’ 5’ 5’ 3’ A U mRNA The genetic code CHMI 2227 - E.R. Gauthier, Ph.D.

  19. The genetic code CHMI 2227 - E.R. Gauthier, Ph.D.

  20. Translation CHMI 2227 - E.R. Gauthier, Ph.D.

  21. fMET = N-formyl methionine The initiation codon is ALWAYS AUG  Methionine Translation - Initiation http://biology.unm.edu/ccouncil/Biology_124/Images/RNAtranslation.jpeg CHMI 2227 - E.R. Gauthier, Ph.D.

  22. Peptide bond: synthesized by the « peptidyl transferase » enzyme on the large ribosomal subunit Translocation Translation - Elongation http://biology.unm.edu/ccouncil/Biology_124/Images/RNAtranslation.jpeg CHMI 2227 - E.R. Gauthier, Ph.D.

  23. Three « Stop » codons exist: UGA; UAA, UAG Translation - Termination http://biology.unm.edu/ccouncil/Biology_124/Images/RNAtranslation.jpeg CHMI 2227 - E.R. Gauthier, Ph.D.

  24. Cue from environment (hormones, temperature, etc) Protein folding Protein function Change in cell behavior Change in organism Adaptation to environment http://www.contexo.info/DNA_Basics/images/gene_expression.gif CHMI 2227 - E.R. Gauthier, Ph.D.

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