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Microwave Thermography. RTM – Principles. The RTM-01-RES radiometer receives and evaluates the natural electromagnetic radiation (temperature) from the patient’s internal tissues at microwave. The Volume Under Investigation. Skin. Internal Tissues. Microwave Sensor.

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Presentation Transcript
rtm principles
RTM – Principles

The RTM-01-RES radiometer receives and evaluates the natural electromagnetic radiation (temperature) from the patient’s internal tissues at microwave

the volume under investigation
The Volume Under Investigation

Skin

Internal Tissues

Microwave Sensor

The Volume Under Investigation

Antenna

P=kTΔF

K-Bolzmann coefficient

ΔF-the receivers bandwidth

temperature and blood flow patterns in breast cancer m gautherie 1982
Temperature and Blood flow Patterns in breast cancer(M. Gautherie 1982)

85000 patients have been examined in three

Breast Centers in France during 17 years.

  • Departement de Senologie, Hospices Civils
  • Unite de Senologie, Hospital de Hautepierre
  • Centre de Senologie
metabolic heat production as a function of doubling time of tumor volume
Metabolic heat production as a function of doubling time of tumor volume

70

60

50

40

30

20

10

0

200

100

300

400

500

600

700

Metabolic heat production,

( мWt/cm3)

Doubling time of tumor volume (days)

m gautherie m onitoring of 1245 women with th iii increase of hyperthermia during 12 years
M. Gautheriemonitoring of 1245 women with Th III increase of hyperthermia during 12 years
  • patients without benign lesions

461 patients with benign mastopathy

slide9

Evolution of cancer for the patients with benign mastopathy and

stable Th III increase of hyperthermia

The percentage of Breast Cancer cases

The number of patients – 461

slide10

Evolution of cancer for the patients without benign lesions and stable Th III increase of hyperthermia

The percentage of Breast Cancer cases

The number of patients– 784

the internal temperature difference as a function of microvessel density mvd
The Internal Temperature Difference as a Function of Microvessel Density (MVD)

T. Yahara, 2003

Internal Temperature Difference

Microvessel Density (MVD)

angiogenesis of breast cancer
Angiogenesis of Breast Cancer
  • Angiogenesis, the process of new blood

vessel formation, play the central role in

both local tumor growth and distant

metastasis in breast cancer.

  • Angiogenesis precedes transformation of

mammary hyperplasia to malignancy

B. P. Schneider, 2005

slide13
Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma,( Weidner,1992)
  • Microvessel density was the only statistically significant predictor of overall survivalamong node-negative women. Only microvessel density and histologic grade showedstatistically significant correlations with relapse-free survival in the node-negative subset
  • Conclusions: microvessel density in the area of the most intense neovascularization in invasive breast carcinoma is an independent and highly significant prognostic indicator for overall and relapse-free survival in patients with early-stage breast carcinoma (I or II by International Union Against Cancer criteria)
microvascular density in preinvasive lesions of the human breast viakava p naccarato ag 2004
Microvascular density in preinvasive lesions of the human breastViakava P., Naccarato AG., 2004
rtm diagnosis
RTM - Diagnosis

The temperature is measured in 9 points of each breast and in two reference points

rtm diagnosis software
RTM-Diagnosis Software

Data of the measured temperatures are automatically stored in the computers memory to be processed.

healthy woman s field
Healthy Woman’s Field

Isotherm step

Right MG Left MG

Temperature(ºC): Minimum 34.8, Mean 35.1, Maximum 35.4

breast temperature field
Breast Temperature Field

Isotherm step

Right MG Left MG

Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3

Breast Cancer internal temperature field

slide23

After the treatment

Right Breast Left Breast

Right Breast Left Breast

Before the treatment

The RTM-01-RES is indispensable for the monitoring of treatment due to the fact that it is absolutely harmless.

This is a sample of the positive dynamics which occur during the treatment of mastitis.

slide24
The clinical trials of RTM -01-RESThe total number of patients is 1207 The breast cancer patients -271
russian scientific center for x ray radiology m oscow russia 2006
Russian Scientific Center for X-ray-radiology,Moscow, Russia, 2006

The main tasks of the clinical trials were:

  • To estimate the level of temperature changes for tumors with different degree of malignancy
  • To estimate the correlation between RTM results and color Doppler ultrasonography results
  • To estimate the sensitivity and specificity of RTM method for breast cancer detection
method and materials
Method and Materials
  • Clinical examination
  • Mammography
  • Ultrasonography
  • Doppler ultrasonography
  • Mamma stintigraphy examination
  • RTM method
  • Biopsy
  • Histology
the evaluation of the thermal changes
The evaluation of the thermal changes

The thermograms were characterized by Th parameters.

The maximum index is Th5, the minimum – Th0.

conclusion
Conclusion:
  • In 90% of breast cancer patients have significant thermal changes.
  • 80% patient with breast cancer in situ have thermal changes captured with the RTM-01-RES.
  • In 50% of cancer in situ cases are accompanied by very strong thermal changes (Th5).
  • 80% of patients with the atypical hyperplasia have thermal changes of mammary glands
  • At the high degree of malignance predominate the maximal thermal changes (Th5), at the intermediate degree of malignance predominates the Th4 thermal changes, at the low degree of malignance over half of the patients have the index Th3 and Th2.
  • The RTM method allows to identify patients having high risk of malignization and needing further examination.
conclusion36
Conclusion

RTM method is very promising method for

to identify patients with the increase risk of

breast cancer. Combination RTM method and

mammography increase sensitivity of breast

cancer diagnosis to 98%