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Exercise and CHD. What is cholesterol used for inside the body and how much do we need?. How is cholesterol involved with atherosclerosis?. Injury – HTN, inflammation, infection, trauma, toxic materials, etc. Fatty streak – monocytes form foam cells which become fatty streaks and plaques

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how is cholesterol involved with atherosclerosis
How is cholesterol involved with atherosclerosis?
  • Injury – HTN, inflammation, infection, trauma, toxic materials, etc.
  • Fatty streak – monocytes form foam cells which become fatty streaks and plaques
  • Migration and aggregation – macrophages secret growth factors for smooth muscle cells, produce reactive oxygen materials which cause LDL to accumulate
  • Lipid accumulation
  • Maturation of the lesion
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