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Embryology of the Reproductive Organs

Embryology of the Reproductive Organs. The entire process of sexual development depends on a sequential series of interactions between regulatory factors and genetic machinery. Stages of Sexual Determination (Differentiation). Chromosomal Determination XX or XY

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Embryology of the Reproductive Organs

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  1. Embryology of the Reproductive Organs The entire process of sexual development depends on a sequential series of interactions between regulatory factors and genetic machinery.

  2. Stages of Sexual Determination (Differentiation) • Chromosomal Determination XX or XY • Gonadal Determination Ovary or testes • Phenotypic determination What do sex organs look like

  3. 1. Chromosomal Determination Ovum 22 Autosomes 1 X chromosome Sperm 22 Autosomes 1 X chromosome or 1 Y chromosome Zygote = 46 XX or 46 XY

  4. Cleavage

  5. Blastocyst

  6. Implantation

  7. Formation of the Placenta

  8. Primordial Germ Cells

  9. 3 Week Embryo

  10. 6 Weeks embryo

  11. 6 weeks

  12. Primordial Germ Cells Genital/GonadalRidge At Six Weeks

  13. TDF

  14. Testes Determining Factor TDF is a gene on the Y chromosome that converts the Gonadal/Genital ridge to a testes Inside a testes you have: • Seminiferous tubules – Spermatogonia inside • Sertoli cells – Produces MIF (Mullerian inhibiting Factor in embryo. • Interstitial cells – Produce Testosterone

  15. Mullerian Duct Gonadal Ridge Wolffian Duct

  16. Gonadal Ridge Mullerian Duct Wolffian Duct

  17. Epidydidimis Vas deferens Degenerating Mullerian Duct Seminal Vesicle

  18. Ovaries Fallopian Tubes Uterus Upper Part of Vagina

  19. Undifferentiated external Genital tubercle Genital groove Genital fold Labioscrotal swelling

  20. Undifferentiated external Genital Tubercle Labioscrotal Swelling Genital Fold Genital Groove

  21. Undifferentiated Stage Genital Tubercle Genital Fold Genital Groove Labioscrotal Swelling

  22. Genital Tubercle Genital Fold Genital Groove Labioscrotal Swelling Glans Penis Penile Rafe Urethra Scrotal Sac

  23. Genital Tubercle Genital Fold Genital Groove Labioscrotal Swelling Clitoris Labia Minor Vaginal and Urethral Opening Labia Major

  24. 7 Months 8 Months

  25. Transabdominal movement Formation of the Inguinal Canal Movement into scrotal sac

  26. Gubernaculum • Phallus • Inguinal Canal • Testes • Abdominal cavity • Vas deferens

  27. Masculanize the Wolffian Duct Testosterone

  28. Masculanize the external genitals

  29. Masculanize the Brain

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