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Mechanisms ● Mortality ● Therapeutics. Rational, Trial Design, and Results of the ADAGIO Delayed Start Trial.

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Mechanisms ● Mortality ● Therapeutics

Rational, Trial Design, and Results of the ADAGIO Delayed Start Trial

C. Warren Olanow, MD, FRCPCHenry P. and Georgette Goldschmidt ProfessorChairman Emeritus, Department of NeurologyProfessor, Department of NeuroscienceDirector, Robert and John M. Bendheim Parkinson's Disease CenterMount Sinai School of MedicineNew York, New York

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Schematic Illustration of the Three Primary End Points of the Study

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

slide3

Randomization and Treatment

of the Study Subjects

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

slide4

Baseline Characteristics

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

slide5

Results for Primary and

Secondary Characteristics

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

slide6

Changes in Scores on the Unified Parkinson’s Disease Rating Scale

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

slide7

Adverse Events

According to Treatment Group

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

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Adverse Events

According to Treatment Group (cont)

Olanow CW, et al. N Engl J Med 2009;361:1268-78.

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Adverse Events

According to Treatment Group (cont)

Olanow CW, et al. N Engl J Med 2009;361:1268-78.