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Exploring Symbiotic Relationships in Amphimedon: Insights into Microbe-Immune Interactions

This study investigates the intricate interactions between the sponge Amphimedon and its microbial symbionts, focusing on how these relationships evolve throughout the sponge's lifecycle. Key questions include methods of symbiont acquisition, changes in bacterial communities over time, and shifts in innate immune gene expression. By understanding these processes, we aim to shed light on the ancient and complex relationships that exist in marine ecosystems, emphasizing the role of both vertical and horizontal transmission of symbionts.

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Exploring Symbiotic Relationships in Amphimedon: Insights into Microbe-Immune Interactions

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  1. The innate immune system as a window into sponge-microbeinteractions Jo Bayes Sandie Degnan School of Biological Sciences UQ

  2. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  3. Ancient, abundant, invisible life forms

  4. Microbial-metazoan interactions • Marine bacteria - freeliving • - pathogenic • - symbiotic • Bacteria 3.5 bya • Sponges 650 mya

  5. Amphimedonqueenslandica • Heron Island • Indo-Pacific distribution • Hermaphroditic spermcast spawner • Broods embryos • First Poriferan genome Srivastavaetal. 2010 • Alpha - proteobacteria bacteria sequenced

  6. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  7. Microbial -metazoan interactions • Symbiont transmission • Vertical - Poribacteria • Horizontal

  8. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  9. Microbial communities Least similar Most similar

  10. Questions • How does Amphimedon acquire its symbionts? • How does the bacterial community of Amphimedonchange throughout its lifecycle? • How does innate immune gene expression change throughout Amphimedon’slifecycle?

  11. Innate Immunity: A first line recognition system • Vertebrates • Innate and Adaptive • Memory cells • Invertebrates • Innate • Alternative adaptive ?

  12. Innate Immunity: A first line recognition system • Pattern Recognition Receptors • Microbial Associated Molecular Patterns Gram positive Gram negative

  13. Amphimedoninnate immune genes of interest

  14. Amphimedoninnate immune gene expression

  15. Conclusions • Symbiotic microbes acquired via vertical and horizontal transmission • Symbiotic from transitory community • Immune genes induced or developmental? • Benthos • Feeding • Thank you... • Sandie Degnan • Bernie Degnan • (School of Biological Sciences, UQ) • Phil Hugenholtz • (Australian Centre of Ecogenomics) • Degnan lab • http://web.me.com/degnanlab1/DegnanLab/Home.html • http://ecogenomic.org/users/jo-bayes

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