1 / 11

Haemochromatosis

Haemochromatosis. Haeme- : ”Of Blood” Chromo- : ”in connection to genetics”. Author Ole Arvid Forså Østerud Subject : Current Health Problems in Home Contries Background : -Connection to syllaby in Physiology -Connection to syllaby in Pathyphysiology -Personal Predisposition.

megara
Download Presentation

Haemochromatosis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Haemochromatosis Haeme- : ”Of Blood” Chromo- : ”in connection to genetics”

  2. AuthorOle Arvid Forså ØsterudSubject: Current Health Problems in Home ContriesBackground: -Connection to syllaby in Physiology-Connection to syllaby in Pathyphysiology-PersonalPredisposition

  3. Charracteristics: • Diseaseconnected to the Iron homeostasis • Caused by • 1. Genetic predisposition • 2. Anemia, Alcoholconsumption • Primary symptoms: • Joint pain • Lackofenergy • Abdominal pain • Secondary symptoms: • Arthritis • Liver disease • DamageofPancreas • Many more • Distribution • One ofthe most commongeneticdiseases in the U.S. • 0,5% ofCaucasionpeopleof North Europenorigin has thedisease

  4. Iron Overload Iron is taken up in theSmallintestine al cryptstheEnterocytes During physiologicalfunctionofthe Iron HomestasistheEnterocytes have a wayofmonitoringthelevelof Iron in theblood According to the Iron level, theuptake rate is regulated In Heamochromatosishowever, there is an errorsomewherebetweentheEnterocyte and thechemoreceptorsensingtheIron concentration in theblood

  5. Iron in human body In Erythorcytes Iron is an essential part of hemoglobin molecule In Plasma Iron is transportedtroughputthe body connected to Transferrin In Tissues Iron is stored in variousplaces in the body, in conjugation to thestoragemoluculeFerritin

  6. Iron in PatientwithHemocromatosis Iron levels in the body are far above normal values In case ofvaluesofFerritinexceeding 300 ng/L, thecondition is consideredpathological and treatmentareneeded Whenthe Iron levelaregreatlyincreasedthe Iron is stored in the form ofHemosiderin Most commonplacesofhemosiderindepostis in case ofHemocromatosis Liver Pancreas Boinymarrow Myocardium Canalsobeenseen in Lungs Skin Brain Joints

  7. Liver in Hemocromatosis HepatictissuewithHemosiderindeposit Healthy liver Hemosiderin depositis

  8. Genetics

  9. Testing

  10. Treatment

  11. Sources and material

More Related