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TL 的文章被 Organic Chemistry Highlights 网站进行了评论

TL 的文章被 Organic Chemistry Highlights 网站进行了评论. Modern Methods for Asymmetric Hydrogenation of Ketones 1. Asymmetric Transfer Hydrogenation (ATH) ( Tetrahedron Lett. 2005 , 46 , 7341).

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TL 的文章被 Organic Chemistry Highlights 网站进行了评论

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  1. TL的文章被Organic Chemistry Highlights网站进行了评论 Modern Methods for Asymmetric Hydrogenation of Ketones 1. Asymmetric Transfer Hydrogenation (ATH) (Tetrahedron Lett.2005, 46, 7341) The reduction of acetophenone (1) could be accomplished by utilizing [RuCl2(p-cymene)2] / ligand (a chiral amino alcohol) in water at room temperature, with quantitative conversions and moderate to high enantioselectivity. Best results were obtained with ephedrine hydrochloride (5 gave optimal enantioselectivity 75% ee and 99.3% conversion). This group found that (-)-ephedrine hydrochloride, a stable, efficient and cost-effective ligand when combined with [RuCl2(p-cymene)2], is an efficient catalyst system for ATH with other ketones and gave excellent yields and good enantioselectivity (up to 83% ee). http://www.organic-chemistry.org/Highlights/2006/05March.shtm

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