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BioInnovation . Kelly Freed, Jenny Heffernan, Emily Rautenberg Client: Dr. Philip Leopold. Computational Biology. Modeling biological reactions using mathematical means to produce simulations to be used in real world applications

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bioinnovation

BioInnovation

Kelly Freed, Jenny Heffernan, Emily Rautenberg

Client: Dr. Philip Leopold

computational biology
Computational Biology
  • Modeling biological reactions using mathematical means to produce simulations to be used in real world applications
  • Allows user to compare computed results with in-lab experimentation
  • Computational means provide a faster and inexpensive substitute to in-lab research
  • Digital data can be used to predict real life results
  • OUR PROJECT: Computationally Model Viral Infection
intro to cell biology
Cell Nucleus

Microtubules

Microtubule Organizing Center

(MTOC)

Intro to Cell Biology

Virus

(adenovirus)

viral infection
Viral Infection

Virus attaches to a cell encapsulated in an endosome, releases into the cytosol, then attaches to the microtubule.

the unknowns
The Unknowns
  • What happens after viruses travel along microtubules?
  • Can the virus bind to the nucleus at any state?
  • How do viruses move from the the MTOC to the nucleus?
  • Is there another intracellular transportation mechanism?
solution
Solution
  • Provide method of testing both known and unknown
  • Create unique experiments through path manipulation
  • Edit state transitions virus can make
possible variables
Possible Variables
  • Cell Size
  • Cell Type
    • Normal
    • Cancerous
  • Number of Viruses
  • Various Rates in a Given State
  • Over 2 million possible experiments!
implementation
Autodesk Maya

Model Creation

Implementation
  • Unity 3D
    • GUI: Javascript
    • Simulation: C#
demonstration

Demonstration

Now let’s see it in action!

future
Future
  • Randomized Microtubule Creation
  • Animation playback and saving capabilities
  • Data Exportation
  • Various Cell Customizability
questions

Questions?

kfreed@stevens.edu, jheffern@stevens.edu, erautenb@stevens.edu