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Herz (Kleintier) PET

Herz (Kleintier) PET. Dopamintransporter. Myokardstoffwechsel. *. Mensch. **. *. Maus. **. Normal. Parkinson. ** Enddiastole, * Endsystole. Striatum. Harder Drüsen der Maus. First-pass PET. Herausforderungen.

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Herz (Kleintier) PET

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  1. Herz (Kleintier) PET

  2. Dopamintransporter Myokardstoffwechsel * Mensch ** * Maus ** Normal Parkinson ** Enddiastole, * Endsystole Striatum Harder Drüsen der Maus

  3. First-pass PET

  4. Herausforderungen Biologisch und medizinisch bedeutsame Moleküle liegen in minimalen Mengen vor (< 0.0001 Gramm pro Gramm Gewebe) Molekulare Bildgebung benötigt eine sehr hohe Empfindlichkeit Spezifität (keine Bindung an andere Moleküle) Aktuelles Verfahren in der Forschung und Klinik: Radioaktiv markierte Moleküle und Positronen-Emissions-Tomographie (PET) Molekulare Bildgebung

  5. a-chain Ca2+ b-chain Ca2+ S S Ca2+ talin a-actinin Structure and function of the v3 integrin • heterodimeric membraneprotein • expressed on activated endothelialcells and some tumor cells (melanoma, glioblastoma) • mediates cellular adhesion and migration during angiogenesis and metastasis formation • binds to an arginine, glycine, aspartate sequence (RGD) of matrix proteins

  6. Cyclic c(RGDfV) peptides bind specifically to the αVβ3, but not to related, RGD binding integrins Imaging the αVβ3 Integrin peptide integrin [nM] avb3 avb5 aIIbb3 c(RGDfV) 13 3,350 6,700 [I]Gluco-RGD 40 2,000 5,000 [F]Galacto-RGD 5 1,000 6,000

  7. Imaging the αVβ3 Integrin 64Cu-DOTA-RGD Delayed images (22 hours post injection) 7 U87 A431 %ID/g 0 CT PET fusion projection Ferl et al. J Nucl Med 2009

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