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Research Update 3/3/11

Research Update 3/3/11. Forrest Jacoby. Overall Goals. The overall goal of my research has been to use Comsol finite element modeling to accurately portray ventricular deformation in hydrocephalus. http://www.upstate.edu/practice/neurosurgery/education/med_students/3v/. Initial Work.

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Research Update 3/3/11

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  1. Research Update 3/3/11 Forrest Jacoby

  2. Overall Goals • The overall goal of my research has been to use Comsol finite element modeling to accurately portray ventricular deformation in hydrocephalus. http://www.upstate.edu/practice/neurosurgery/education/med_students/3v/

  3. Initial Work • My first model was a simple compressive deformation of a tube of brain material. • This can’t explain all deformation.

  4. Conditions of Model • Tube is poroelastic material with properties of brain matter • Walls of the tube are impermeable and stationary. • Fluid pressure is applied within the tube. • Biot-Willis coefficient between porosity and unity [1].

  5. Table of Values

  6. Results of ModelingBiot-Willis=1.00 Comsol 3.5a

  7. Results of ModelingBiot-Willis=.75 Comsol 3.5a

  8. Analysis of Modeling • Ventricle area increased 16% • Hydrocephalus has an increase in Atrial Ventricular diamater of ~100% (or 300% increase in area)[4]. • I need to use a different model. I think a model with softer wall conditions will be required.

  9. Problem With Fluid Filled Balloons • Comsol doesn’t like fluid filled balloons. • Tube with flow and pressure fails to converge. • Fluid source term fails to converge. • Comsol Community stymied.

  10. Works Cited 1. Wang, Herbert. Theory of Linear Poroelasticity with Applications to Geomechanics and Hydrogeology. Princeton, NJ: Princeton UP, 2000. Print. 2. Kaczmarek, Mariusz, Ravi P. Subramaniam, and Samuel R. Neff. "The Hydromechanics of Hydrocephalus: Steady-state Solutions for Cylindrical Geometry." Bulletin of Mathematical Biology 59.2 (1997): 295-323. Science Direct. Web.

  11. 3. Li, X. G., H. Von Holst, J. Ho, and S. Kleiven. "3-D Finite Element Modeling of Brain Edema: INitial STudies on Intracranial Pressure Using Comsol Multphysics." Comsol. Proc. of COMSOL Conference 2009 Milan. Web. <http://www.comsol.com/papers/6687/>. 4. Farrell, T. A., B. S. Hertzberg, M. A. Kliewer, L. Harris, and S. S. Paine. "Fetal Lateral Ventricles: Reassessment of Normal Values for Atrial Diameter at US." Radiology 193 (1994): 409-11.Radiology.rsna.org. Web. <http://radiology.rsna.org/content/193/2/409.abstract>.

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