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This anemia is characterized by larger-than-normal bone-marrow cells (megaloblastic) and as a result, larger-than-normal (macrocytic) red blood cells are released into circulation. Read more: https://masteranesthesia.com/anemia-macrocytic-megaloblastic/
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Anemia – Macrocytic/Me galoblastic
Anesthesia Implications: 100% O2 – Anemia, in general, is an impairment of the body’s ability to transport O2 to the tissues. Unless contraindicated, give the patient 100% O2 and ensure proper ventilation. PBRCs (if life threatening) – if this condition has the potential to be life threatening, administer packed red blood cells (PBRCs) Avoid nitrous oxide – nitrous oxide impairs vitamin B-12 activity, which can further contribute to anemia.
Pathophysiology: This Anemia Macrocytic Megaloblastic normally manifests as Hemoglobin levels < 10 g/dL, mean RBC volume of 110-140 fL (normal = 90 fL), normal reticulocyte count, increased levels of LDH and bilirubin. This anemia is characterized by larger-than-normal bone-marrow cells (megaloblastic) and as a result, larger-than-normal (macrocytic) red blood cells are released into circulation.
Pathophysiology: This Anemia Macrocytic Megaloblastic normally manifests as Hemoglobin levels < 10 g/dL, mean RBC volume of 110-140 fL (normal = 90 fL), normal reticulocyte count, increased levels of LDH and bilirubin. This anemia is characterized by larger-than-normal bone-marrow cells (megaloblastic) and as a result, larger-than-normal (macrocytic) red blood cells are released into circulation.
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