Wes Van Voorhis Fellows Course 2010. Travelers’ and Tropical Medicine. 28 yo female with fever. Fevers began one day ago Hectic pattern Returned 2 d ago from rural Nigeria No food/water precautions Mosquito bites No malaria prophylaxis: “Did not need as a child” growing up in rural Nigeria
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Travelers’ and Tropical Medicine
“Common” Binding types and Malaria During Pregnancy
Fried & Duffy. Science. 1996.
Fried M. et al. Nature. 1998.
Since PfEMP1 proteins bind CD36, this suggests the parasite switches to non-CD36
binding variants to ensure sequestration in placenta and not microvasculature.
L. tropica: Urban leish., dry type, more common in
Afghanistan, particularly in Kabul
1. Reaches adulthood only in cats and dogs
2. Life cycle similar to human hookworm
3. In humans, filariform larvae penetrate skin
4. Remains in skin, does not reach maturity
1. Eggs and larvae require warm moist temperatures
2. Beaches and areas under houses contaminated
3. In USA southern Atlantic and Gulf states
1. Severe itching
2. Red linear skin lesions (15 to 20 cm)
3. Secondary bacterial infections
1. Eosinophilia rare
2. Larvae rarely found in skin biopsy
1. Ivermectin or albendazole p.o.
2. Thiabendazole applied topically
3. Treat bacterial infections
1. Untreated lesion may persist for weeks or months
2. Therapy usually successful
(Fansidar or Malarone for vivax?)
(P. malariae ChloroR is now reported)
43 y.o. male after visiting Panama,
Lake fishing at 1,500 ft altitude
Third instar larva of Cordylobia anthropophaga, the Tumbu fly.The powerful mouth hooks, with which the larva feeds, are seen as long, dark bars.
Extracting a larva of Cordylobia anthropophaga after covering it with paraffin. The pair of black spiracles can just be seen in the centre of the posterior tip of the larva.