Hepatitis D (Delta) Virus - PowerPoint PPT Presentation

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Hepatitis D (Delta) Virus

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Hepatitis D (Delta) Virus
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Hepatitis D (Delta) Virus

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  1. Hepatitis D (Delta) Virus d antigen HBsAg RNA

  2. Hepatitis D - Clinical Features • Coinfection • severe acute disease • low risk of chronic infection • Superinfection • usually develop chronic HDV infection • high risk of severe chronic liver disease

  3. Hepatitis D Virus Modes of Transmission • Percutanous exposures • injecting drug use • Permucosal exposures • sex contact

  4. HBV - HDV Coinfection Typical Serologic Course Symptoms ALT Elevated anti-HBs Titer IgM anti-HDV HDV RNA HBsAg Total anti-HDV Time after Exposure

  5. HBV - HDV Superinfection Typical Serologic Course Jaundice Symptoms Total anti-HDV ALT Titer HDV RNA HBsAg IgM anti-HDV Time after Exposure

  6. Geographic Distribution of HDV Infection Taiwan Pacific Islands HDV Prevalence High Intermediate Low Very Low No Data

  7. Hepatitis D - Prevention • HBV-HDV Coinfection • Pre or postexposure prophylaxis to prevent HBV infection • HBV-HDV Superinfection • Education to reduce risk behaviors among persons with chronic HBV infection