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Evolutionary Genetics: Unraveling Human History and Health through DNA Tales

Explore the fascinating world of genetics and human evolution, from Hemochromatosis to Vitamin D sun exposure effects. Discover how genetic code holds the legacy of our ancestors' survival through plagues, predators, and more. Uncover the connections between common genetic traits and historical events, shedding light on our complex biological heritage. This insightful journey offers a deeper understanding of how our genes shape our health and interactions with the environment.

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Evolutionary Genetics: Unraveling Human History and Health through DNA Tales

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  1. Introduction • Hemochromatosis • Alzheimer's • Constant company • A global, evolutionary Macarena • It’s not only good for X-Men • DNA is history • Somewhere in your genetic code is the tale of every plague, every predator, every parasite, and every planetary upheaval your ancestors mangled to survive

  2. Chapter 1 • Hemochromatosis is inherited—and the gene for it is very common in certain populations • Iron Locking- Vivkings- founder’s effect • Bubonic plague: 1/3 to ½= 25 million people • People with Hemochromatosis are less susceptible? • Increase in European populations every time the disease resurfaced over the ensuing three hundred years • Evolutionary bottleneck • We did ask for it! • Cystic fibrosis and TB

  3. Chapter 3 • Sunlight: Vitamin D and Folic Acid • Skin Color • Dark to protect folate • Light to manufacture vitamin D • Inuit • High cholesterol to increase vitamin D • ACHOO • Alcohol flush response (alcohol vs. tea) • Slave trade and salt- evolutionary bottleneck • Environmentally dependent • What happens when the environment changes (moves or migrations?)

  4. Chapter 4 • The fava bean- Where’s there folklore smoke, there’s medical fire • Free radicals and enzyme deficiency • Fava cultivation and favism • >400 million • Fruit, botanical birth control & poison • JBS Haldane • SCD • Favism • Malaria • Why cultivate what can kill you?

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