1 / 17

PASS & NACC FTD Study

PASS & NACC FTD Study. Daisy Sapolsky, MS, CCC-SLP Speech Language Pathologist MGH Frontotemporal Disorders Unit MGH Department of Speech, Language and Swallowing Disorders & Reading Disabilities. National Alzheimer’s Coordinating Center (NACC). NACC overview:

manuela
Download Presentation

PASS & NACC FTD Study

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. PASS & NACC FTD Study Daisy Sapolsky, MS, CCC-SLP Speech Language Pathologist MGH Frontotemporal Disorders Unit MGH Department of Speech, Language and Swallowing Disorders & Reading Disabilities

  2. National Alzheimer’s Coordinating Center (NACC) • NACC overview: • Alzheimer’s Disease Centers (ADCs) were established in 1984 • MGH was one of the first five to receive grants • NACC was then established in 1999 by the National Institute on Aging • To facilitate collaborative research among the 29 ADCs nationwide • NACC maintains a large database of the data collected at these visits, which is a valuable resource for ongoing research http://www.alz.washington.edu/

  3. National Alzheimer’s Coordinating Center (NACC) • NACC overview: • Participation in NACC involves annual visits • neurological examination and interview • neuropsychological testing • interview with a relative/friend • MGH NACC cohort includes: • 709 people being actively followed • 320 people with normal cognition • 330 people with some form of MCI • 266 people with some form of dementia

  4. NACC FTD Study • NACC FTD study: • In pilot phase for the past year (6 centers) • MGH ready to begin administration of the NACC FTD module • Goals: • To capture the cognitive changes of FTD through use of a tailored evaluation • To collect uniform data on patients with FTD from centers across the country • data may be helpful in clinical trial design

  5. Clinical Dementia Rating (CDR) • Tools for quantifying severity and progression of dementia: • Clinical Dementia Rating (CDR) • 5-point scale to rate stages of dementia • no cognitive impairment to severe impairment • six domains of functioning are assessed through interview and patient performance on testing • Memory, Orientation, Judgment and Problem solving, Community Affairs, Home and Hobbies, Personal Care • two supplemental domains added in 2006: • behavior and language

  6. Progressive Aphasia Severity Scale (PASS) • PASS (2008) • A “big picture” clinical tool to rate symptom severity in a variety of speech/language domains in people with progressive aphasia • Modeled after the CDR supplemental language box, a rating of overall language impairment • Clinicians use their judgment to rate presence and severity of impairment in each domain, capturing change from the patient’s baseline

  7. Progressive Aphasia Severity Scale (PASS) • Captures information about symptoms, whereas performance-based testing captures signs of impairment; • Presumably the two together will provide more information than either alone • Some patients perform surprisingly better on testing than in daily life; • Others are much more capable of communicating in conversation than they are of performing on tests

  8. Progressive Aphasia Severity Scale (PASS) • All domains rated from normal to severe impairment, like the CDR: • 0 (normal), 0.5 (questionable), 1 (mild), 2 (moderate), 3 (severe) • Articulation • Syntax/grammar • Fluency • Word retrieval and expression • Repetition • Auditory comprehension • Single word comprehension • Reading • Writing • Functional communication

  9. Progressive Aphasia Severity Scale (PASS) http://www.ftd-boston.org/

  10. PASS profile: Patient A Decline was most significant in the areas that were initially affected while preserved domains remained areas of strength. Relatively fast progression of symptoms.

  11. PASS profile: Patient B Ratings were stable or changed only slightly (0.5) over 2 years, indicating a relatively slow rate of progression with many areas of relative strength. Relatively slow progression of symptoms.

  12. Progressive Aphasia Severity Scale (PASS) • Potentially useful for: • Generating a profile of strengths and weaknesses • Determining PPA subtype • Monitoring disease progression • Capturing response to treatment in clinical trials • speech-language therapy • drug treatments

  13. PASS Paper Neurology, 2010

  14. NDM Paper Neurodegenerative Disease Management, 2011

  15. PASS – Next Steps • Next steps: • Continue longitudinal analysis on the performance of the PASS and imaging methods as clinical and imaging markers for diagnosis and monitoring • Partner with other centers in the U.S. and worldwide to use the PASS • Training materials in development

  16. Global partners in using PASS Northwestern University Central Michigan University University of California, San Francisco • International interest: • Nantes University Hospital, Nantes, France • War Memorial Hospital, Sydney, Australia

  17. Questions • Questions?

More Related