Experiment 18:. THE GRIGNARD REACTION. Objectives:. To synthesize a 3 o alcohol from an alkyl halide and a ketone using a Grignard reaction. To purify product using a liquid extraction method. To determine purity using GC analysis.
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THE GRIGNARD REACTION
R-X + Mg-------------> R-Mg-X
Where R= 1o, 2o, or 3o alkyl, aryl or alkenyl
X= Cl, Br, I
3….which reacts with water when aqueous HCl is added, undergoing hydrolysis to form the product alcohol.
1. The Lewis acid Mg2+ forms an acid-base complex with the basic oxygen atom of the ketone, making the carbonyl group a better acceptor.
2. Nucleophilic addition of butyl group to acetone produces a tetrahedral intermediate…
CaSO4 drying tube in adapter
Record retention times for ALL peaks in standard chromatogram!
Record retention times and area % for ALL peaks present in sample chromatogram!
Calculate AA% for REACTANTS AND PRODUCT only!