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HLA-A2 in MHC Class I Complex: Implications for Presentation of HERPES Viral Peptides

Explore the significance of HLA-A2 in the Major Histocompatibility Complex (MHC) Class I structure and its role in presenting HERPES viral peptides to Cytotoxic T Lymphocytes (CTL). Learn about the formation and synthesis processes involving MHC components such as Calnexin (Cnx), Calreticulin (Crt), Tapasin (Tpn) and the MHC α-chain (HC). Discover how U21 down-regulates MHC Class I and the potential future advancements like X-ray crystallization of MHC and diversion to lysosomal compartments. Uncover alternate evasion strategies involving NK cells and understand MHC interactions and peptide presentation in detail.

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HLA-A2 in MHC Class I Complex: Implications for Presentation of HERPES Viral Peptides

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  1. Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides Joshua Nord Lora Rapp Nathaniel Wanish Concordia University of Wisconsin

  2. Big Picture Human immune system - Cytotoxic T lymphocytes (CTL) - Viral peptide presentation Major Histocompatibility Complex Class I (MHC) -structure Human Herpesvirus-7

  3. Class I MHC Formation Synthesis Cnx = Calnexin HC = MHC α-chain Crt = Calreticulin Tpn = Tapasin

  4. U21 Down regulation of MHC Class I

  5. The Future X-ray crystallization of MHC & U21 Diversion of MHC to lysosomal compartments Alternate NK cell evasion

  6. MHC in the Classroom Model - interactions - anchor residues - peptide presentation

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