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Medical Diagnostics NIAID Funding Opportunities Maria Y. Giovanni, Ph.D. Assistant Director for Microbial Genomics and Advanced Technologies National Institute of Allergy & Infectious Diseases Department of Health and Human Services July 14, 2003.

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Medical DiagnosticsNIAID Funding OpportunitiesMaria Y. Giovanni, Ph.D.Assistant Director for Microbial Genomics and Advanced TechnologiesNational Institute of Allergy & Infectious DiseasesDepartment of Health and Human ServicesJuly 14, 2003

national institute of allergy and infectious diseases nih
National Institute of Allergy and Infectious Diseases, NIH

Mission

Supports basic and applied research to prevent, diagnose and treat infectious and immune-mediated illness, including HIV/AIDS, and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies.

niaid medical diagnostics
NIAID Medical Diagnostics
  • Identify infectious agents in clinical samples including SARS coronavirus, NIAID Category A, B, C agents, other infectious agents, genetically engineered or manipulated organisms and toxins
  • Rapid, highly sensitive, specific, easy to use and interpret, reliable, multi-plexed, and cost effective medical diagnostics for public health laboratories or point-of-care agents or their toxins.
  • Identify early infection or exposure for early detection and intervention
  • Identify/distinguish the agent from common infections
  • Fully integrated systems from front end sample preparation to molecular detection systems with data acquisition and analysis.
medical diagnostics
Medical Diagnostics

Emerging,

Innovative

Technologies

Dev

Technologies

Early Stage

Product

Dev

Technologies

Later Stage

Product /Platform

Dev/Validation

R Platform

Cooperative Initiative

Partnership Initiative

SBIR/STTR

Early Diagnosis/Pre-Symptomatic

Pathogen/Host

Monitoring Infection and Treatment

Pathogen/Host

nih niaid
NIH/NIAID
  • Support basic and applied research by peer-reviewed grants and contracts to public or private institutions and for-profit and non-profit organizations
  • Two approaches
    • Investigator-initiated grants
    • Targeted initiatives supporting both grants and contracts-PA, RFA, RFP
  • Allows support for diverse research projects
niaid cooperative research program for biodefense sars
NIAID Cooperative Research Program for Biodefense & SARS

Goal

Support research projects that will advance the development a product in a cooperative program with NIAID

- Vaccines

- Adjuvants

- Therapeutics

- Diagnostics

- Resources

niaid biodefense sars partnerships
NIAID Biodefense & SARS Partnerships

Goal

Assist private sector in further development of high priority products for biodefense in a cooperative program with NIAID

- Vaccines

- Adjuvants

- Therapeutics

- Diagnostics

- Resources

niaid small business biodefense grant program
NIAID Small Business Biodefense Grant Program

Goal

To support Small Business Innovation Research and Small Business Technology Transfer Research grants to stimulate technological innovations to develop:

- Vaccines

- Adjuvants

- Therapeutics

- Diagnostics

- Resources

slide18

Microbial Sequencing Centers

Genomic Data

Bioinformatics

Centers

Data Warehouse

Data Analysis

PFGRC

Resources

Reagents

Proteomic

Centers

Early Target Ident.

HT-Cloning/Expression

Basic Research

Strain

Identification

Molecular Genotyping

Microbial

Biology

Pathogenesis

Host

Response

Human

Genetic

Variations

Diagnostics

Tech.Dev.

Early Identification of Targets

Vaccines, Drugs and

Target Identification

slide19

NIAID Microbial Genome Sequencing Centers

Goal: Rapid and cost efficient production of high quality genome sequences of human pathogens and invertebrate vectors of diseases

Features:

  • NIAID-supported Contract Sequencing Facility
  • Capacity to sequence genomes for:
    • Scientific community
    • Responding to national needs
    • Other government agencies
  • Anticipated Funding: Late 2003
niaid pathogen functional genomics resource center
NIAID Pathogen Functional Genomics Resource Center

Goal: Develop and distribute technologies and resources for functional analysis of pathogens at whole genome or whole cell/organism level

niaid pathogen functional genomics resource center21
NIAID Pathogen Functional Genomics Resource Center

Genomic Resources Provided:

  • cDNA microarrays
  • Genetic Variation/SNP analysis
  • Develop computational tools for array and comparative genomic data analysis
  • Web site
  • Distribute organism-specific arrays and protocols to scientific community
  • Provide reagents-microbial strains, clones or isolates, libraries, PCR primers
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NIAID Bioinformatics Resource Centers

Goal: Provide the Scientific Community with a robust point of entry for access of genomic and related data in a user-friendly format.

Components

- Database

  • Genomic and Related Data

- Analysis Center

  • Develop and Provide Software Tools

- Multi-disciplinary Team

  • Bioinformatics and Database Experts and Organism-Specific Biologists
niaid proteomics initiative
NIAID Proteomics Initiative

Title: Biodefense and Emerging And Re-emerging Proteomics Research Programs: Identifying Targets for Therapeutic Interventions Using Proteomic Technology

Goal: Characterize the pathogen and/or host cell proteome, identifying proteins associated with biology of microbes, mechanisms of microbial pathogenesis, and host response to infection with the goal of discovering targets for potential candidates for the next generation of vaccines, therapeutics, and diagnostics.