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Study on HEV Vaccination Approach in Swine for Public Health protection

Study on HEV Vaccination Approach in Swine for Public Health protection. Jeanette van der Goot, Jantien Backer, Leo van Leengoed, David Rodriquez Lazaro, Franco Ruggeri, Alessandra Berto, Francesca Martelli, Ivo Pavlik, Wim H. M. van der Poel. Pig finishing farm industry. finishing farm.

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Study on HEV Vaccination Approach in Swine for Public Health protection

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  1. Study on HEV Vaccination Approach in Swine for Public Health protection Jeanette van der Goot, Jantien Backer, Leo van Leengoed, David Rodriquez Lazaro, Franco Ruggeri, Alessandra Berto, Francesca Martelli, Ivo Pavlik, Wim H. M. van der Poel

  2. Pig finishing farm industry finishing farm Weaning 10 weeks of age ± 25 kg Slaughter 28 weeks of age ± 110 kg

  3. SEIR Model for HEV in pigs latently infected infectious recovered susceptible Experimental data (Bouwknegt et al. 2007): Transmission parameter: 0.66 infections per day per infectious animal Latent period: 3 (0.8 – 6.3) days Infectious period: 25.8 (7.0 – 54) days

  4. Age distribution at high transmission susceptible latently infected infectious recovered total R0 = 17 proportion of population weeks of age age at entry age at slaughter

  5. Age distribution at lower transmission susceptible latently infected infectious recovered total R0 = 2.6 R0 = 2.6 proportion of population weeks of age age at entry age at slaughter

  6. Infection dynamics at high transmission susceptible latently infected infectious recovered total R0 = 17 number of animals time (days) time of infection

  7. Infection dynamics at lower transmission susceptible latently infected infectious recovered total R0 = 2.6 number of animals time (days) time of infection

  8. Infectious period distribution uncensored censored infectious period (days)

  9. Partners/ sampling countries • United Kingdom VLA (data available) • Czech Republic VRI • Spain ITACyL • Italy ISS • Netherlands Utrecht University

  10. Farm sampling schedule • One HEV-positive farm per country • Sampling by taking anal swabs • Sampling of 2 pigs per pen • Total nr of samples in a farm of 10 compartments incl. 10 pens: 2 * 10 * 10 = 200 samples

  11. Time schedule task 6.4 • Farm sampling: April 2009 – June 2010 • Testing of samples: June 2009 – August 2010 • Data evaluations: August 2010 – Dec 2010 • Modeling: Jan 2011- Feb 2011 • Publication: March 2011- April 2011

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