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Buruli Ulcer. Arwen Frick-Cheng Bio 402. What is Buruli Ulcer?. Infectious disease Characterized by the WHO as a Neglected Tropical Diseases (NTD) 14 NTD Widely disregarded by industrial nations. What is Buruli Ulcer?. Regions/People Affected. Tropical wetlands and rainforest

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buruli ulcer

Buruli Ulcer

Arwen Frick-Cheng

Bio 402

what is buruli ulcer
What is Buruli Ulcer?
  • Infectious disease
  • Characterized by the WHO as a Neglected Tropical Diseases (NTD)
    • 14 NTD
    • Widely disregarded by industrial nations
regions people affected
Regions/People Affected
  • Tropical wetlands and rainforest
    • Mainly: West and Central Africa
  • Associated with bodies of stagnant water
  • The immunocompromised
  • The poor
  • Children
causative agent
Causative Agent
  • Mycobacterium ulcerans
  • Related to Tuberculosis, Leprosy

Colonies of Mycobacterium ulcerans.

http://www.public.asu.edu/~shaydel/research_002buruli.html

identification of bacteria
Identification of Bacteria
  • Acid Fast Stain
  • Selective Culture
  • Histopathology
  • PCR

Acid-fast stain of Mycobacterium ulcerans.

http://www.who.int/buruli/information/diagnosis/en/index14.html

symptoms
Symptoms
  • Long latent period
  • Usually on exposed body parts
  • Four stages
virulence factor
Virulence Factor
  • Toxin: Mycolactone
    • Immunosupressant
    • Necrosis
treatment
Treatment
  • Antibiotic
    • Rifampicin
  • Surgical removal/amputation
  • Vaccination (BCG)
  • Alternatives
    • Heat treatment
    • French Clay
    • Topical nitrogen oxides
  • Will slowly heal on its own
effects
Effects
  • Heavy scarring
    • Contracture of limbs
    • Blindness
  • secondary infections
references
References
  • Neglected Diseases Caused By Bacterial Infections. M. Bechtle, S. Chen and T. Efferth. Current Medicinal Chemistry, 2010, 17, 42-60
  • Laboratory diagnosis of Buruli ulcer disease. Marcus Beissner, Karl-Heinz Herbinger & Gisela Bretzel. Future Science Group
  • MycolactoneInhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism.Rachel E. Simmonds et al. J. Immunol. 2009;182;2194-2202