Introduction. More than 250 unique RBC antigens have been Documented to date Around 30 Blood group antigens assigned Most discovered in the course of blood transfusion. Biological Functions of Blood group Systems. Blood group Ag: On cell surface of Molecules with Wide Structural Diversity
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*Mediated by CD35(CR1)[Carrier of Knops]; so Helgenson Phenotype (CR1-) unable to form Rosette
** Protective Endothelial Receptors and Cryptic RBC Antigens like on Attached Band3
Adhesion molecules with or associated with blood groups. Schematic representation of red cell membrane adhesion proteins with blood group specificity. The region (light grey) above the phospholipid bilayer (4-5 nm) represents the “glycocalix” (about 12 nm). The Ig-like domains of IgSF protein members are indicated as well as the ligand(s) when known.
DARC = Duffy Antigen / Receptor for Chemokine
Children with Nephropathy
Hemolytic Uremic Syndrome
Endothelial cells at Inflammatory sites in acute Renal Transplant Rejection
7-TM Glycoprotein/G-Protein Coupled
Receptor for ProinflammatoryChemokines (Homology with IL-8 receptor) WBC Activation
Receptor for P. vivax and HIV-1
DARC Binds CC & CXC