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Understanding Gene Expression Biomarkers: The Key to Personalized Medicine

Explore the world of gene expression biomarkers - a set of identified gene sequences with unique expression values, allowing for personalized profiling and scoring. Discover tools like MammaPrint and GenSigDB to access significant gene lists from PubMed articles. Overcome challenges of integrating gene lists into research articles without clear algorithms for new profiles.

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Understanding Gene Expression Biomarkers: The Key to Personalized Medicine

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  1. BiomarkersHCLS F2F 2009-11-03 Michael Miller

  2. Gene Expression Biomarker Definition • A set of sequences/genes/transcripts identified via some sequence database (Entrez Gene, GenBank, Affymetrix,…) • Each sequences’ expression value • An algorithm that allows a new gene expression profile to be matched against the Biomarker and produces a score

  3. MammaPrint MammaPrint Figure 2 Nature 415, 530-536(31 January 2002) doi:10.1038/415530a

  4. GenSigDB • http://compbio.dfci.harvard.edu/genesigdb/ • Significant Gene Lists from PubMed Articles • Does not include signatures • Hosted by Dana Farber Cancer Institute

  5. Challenges • Gene Lists are embedded in articles • Often there is no clear algorithm included in articles to add new gene profiles

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