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A Promising Chemotherapy Agent, Gd@C82(OH)22

A Promising Chemotherapy Agent, Gd@C82(OH)22. Ning Zhang Tianjin Medical University Cancer Institute and Hospital UICC 2008. Chemotherapies have always been accompanied with serious side effects. Can nanoparticles provide a new approach to design low toxic therapeutic agents?.

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A Promising Chemotherapy Agent, Gd@C82(OH)22

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  1. A Promising Chemotherapy Agent, Gd@C82(OH)22 Ning Zhang Tianjin Medical University Cancer Institute and Hospital UICC 2008

  2. Chemotherapies have always been accompanied with serious side effects. Can nanoparticles provide a new approach to design low toxic therapeutic agents?

  3. Treatments with Gd@C82(OH)22 Inhibit hepatoma growth in a mouse model 0.28 mg/kg 1.20mg/kg Gd@C82(OH)22 inhibits tumor growth in a breast tumor model. Nano Lett Vol 5, pg 2050

  4. Gd@C82(OH)22 doesn’t show cytotoxicity

  5. Treatments with Gd@C82(OH)22 reduced blood supply to tumors

  6. Treatments with Gd@C82(OH)22 reduced blood vessel density

  7. Treatments with Gd@C82(OH)22 induced a massive leukocyte infiltration in tumors.

  8. Gd@C82(OH)22 induced iDC maturation and TH-1 response.

  9. Treatments with Gd@C82(OH)22 cancer cell chemotaxis and metastasis

  10. Summary • Treatment with Gd@C82(OH)22 inhibits tumor growth without detectable toxicity. • 2. Gd@C82(OH)22 doesn’t show cytotoxicity. • 3. Gd@C82(OH)22 inhibits blood supply to tumor tissues. • 4. Gd@C82(OH)22 induced tumor immunity. • 5. Gd@C82(OH)22 inhibits cancer cell chemotaxis Blood supply Tumor immunity Metastasis

  11. Chinese Academy Institute of High Energy Physics Tianjin Cancer Institute and Hospital National Center of Nanotechnology Research Center for Cancer Nanotechnology

  12. Acknowledgements Dr. Yujie Ma Dr. Guoguang Ying Dr. Ruifang Niu Nanosafety Lab, Chinese Academy of Science Dr. Yuliang Zhao, Director Dr. Gengmei Xing Huan Meng Laboratory of Molecular Immunoregulation, NCI Dr. Joost Oppenheim, Chief Dr. De Yang

  13. Gd@C82(OH)22 induced a dendritic cell maturation

  14. Gd@C82(OH)22 induced a dendritic cell to express CCR7 receptors HR (100 ug/ml)-treated DCs migrated to SLC but not Rantes, suggesting the HR-treated DCs were mature DCs.

  15. T cell cytokine production in response to Gd@C82(OH)22-treated DCs

  16. Treatments with Gd@C82(OH)22 disrupted the integrity of capillary blood vessels in tumors.

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