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Understanding the Role of IKK Kinase in IκBα and NF-κB Signaling Pathway

Explore the intricate mechanism of IKK kinase in the regulation of IκBα and NF-κB signaling pathway, including nuclear translocation, proteasomal degradation, and its impact on cellular transformation and differentiation. Learn how retinoids influence this pathway and potential implications for malignant progression and reversion.

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Understanding the Role of IKK Kinase in IκBα and NF-κB Signaling Pathway

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  1. IkB kinase IB p50 p65 UB UB UB p Nuclear Translocation p IB RAR/RXR Retinoids Proteosomal Degradation p50 p65 Transformation and Malignant Progression kB site RAR/RXR Retinoids Differentiation and Malignant Reversion RARE Nucleus Cytosol

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