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PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI

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PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI. CANCER. Cancer is characterized by abnormal, unrelated cell proliferation Cancer invades healthy tissues and compete with normal cells for oxygen, nutrients, and space

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slide1
PROLIFERAZIONE CELLULARE

E RESISTENZA AI FARMACI

cancer
CANCER
  • Cancer is characterized by abnormal, unrelated cell proliferation
  • Cancer invades healthy tissues and compete with normal cells for oxygen, nutrients, and space
  • Abnormal cells reproduce in the same way as normal cells, but they do not have the regulatory mechanisms to control growth
  • The abnormal cell growth proliferates in an uncontrolled and unrestricted way.
cancer3
CANCER
  • Tumors are also classified according to their cell of origin and whether their growth is benign or malignant
  • BENIGN tumors remain at their site of origin
    • They may grow large, but their growth rate is slower than that of malignant tumors
    • They usually do not cause death unless their location impairs the function of a vital organ
  • MALIGNANT tumors grow rapidly are likely to undergo metastasis (See table 20-2)
slide5
Epithelial cells = carcinomasConnective tissues or muscle = sarcomasHemopoietic cells = leukemiasPigments producing cells of the skin = melanoma
6 key behaviors of cancer cells
6 key behaviors of cancer cells
  • They disregard the external and internal signals that regulate cell proliferation
  • They are resistant to apoptosis
  • The avoid limitations to proliferation, such as differentiation and senescence
  • They are genetically unstable
  • They are invasive (escape home tissue)
  • The metastasize (survive and proliferate in foreign tissues)
slide7
Clonal

Evolution

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