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Center for Craniofacial and Dental Genetics (CCDG) U of Pittsburgh SDM, Dept of Oral Biology

Center for Craniofacial and Dental Genetics (CCDG) U of Pittsburgh SDM, Dept of Oral Biology Mary L. Marazita, Ph.D. CCDG Director. History. The CCDG was founded in 2001 Early research at the center was focused primarily on orofacial clefts (cleft lip/palate).

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Center for Craniofacial and Dental Genetics (CCDG) U of Pittsburgh SDM, Dept of Oral Biology

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  1. Center for Craniofacial and Dental Genetics (CCDG) U of Pittsburgh SDM, Dept of Oral Biology Mary L. Marazita, Ph.D. CCDG Director

  2. History The CCDG was founded in 2001 Early research at the center was focused primarily on orofacial clefts (cleft lip/palate). Initially the research arm of the University SDM’s Cleft-Craniofacial Center (no longer in the Dental School) In 2003, the CCDG moved from it’s original location in Salk to an expanded space off campus. The CCDG expanded again in 2010, doubling the total space The CCDG is now a major international center for craniofacial and oral health research.

  3. CCDG Faculty, Staff and Students Primary Faculty Mary Marazita (Director) Manika Govil Kathy Neiswanger Petr Pancoska Alex Vieira Seth Weinberg Affiliated Faculty Eleanor Feingold (HuGen) John Shaffer (HuGen) Adriana Modesto Vieira (SDM) Dan Weeks (HuGen) Robert Weyant (SDM) + other Oral Biology Post-Docs Elizabeth Leslie • Staff • 30 full and part-time staff members, including project and database managers • Students • Too many to name • OB grad students • HuGen, Epi, Biostatgrad students • Dental students • Residents • Undergrads • MANY USA AND ITERNATIONAL COLLABORATIONS

  4. Location and Physical Space We are located slightly off campus 100 Technology Drive, Pittsburgh, PA, 15219 “Bridgeside Point I” or “Thermo Fisher” Building Salk • How can you get to us from Salk? • Campus shuttle (2nd Ave or Biotech) • Car • Bike • Walk (about 15-20 min)

  5. Location and Physical Space • By the Numbers • Located on two different floors (4th and 5th) • 19000 sqfttotal • 8000 sqft5th floor (original space) • 11000 sqft4th floor (added in 2010) Amenities 35 private offices 40 semi-private cubicals Subject assessment space Conference rooms Imaging and Morphometrics Lab (Weinberg, Director) Two wet labs Kitchens Outdoor deck area

  6. Research The CCDG receives about $5 million in funding annually Major funding source is the National Institute for Dental and Craniofacial Research (NIDCR) http://www.nidcr.nih.gov/ Major Research Themes: Orofacial Clefting Oral Health Etiology and Disparities

  7. OrofacialClefting

  8. Research OROFACIAL CLEFTING: PHENOMICS AND GENOMICS Oldest research focus of the CCDG (started in 1990’s). Major goal is to identify genes that contribute to cleft risk. Clefting is the most common craniofacial birth defect (1/500 – 1/2500) Our approach is unique, because we focus on incorporating subclinical risk phenotypes into our analyses. Major international effort. Research sites and collaborators on every continent Over 12,000 subjects have been recruited. CCDG Faculty involved: Marazita, Weinberg, Vieira, Feingold, Shaffer, Govil, Pancoska

  9. Oral Health and Disease

  10. Research CENTER FOR ORAL HEALTH RESEARCH IN APPALACHIA Goal is to identify factors (genetic, environmental, and microbial) that contribute to oral health and disease. COHRA started in 2009. Two major recruitment efforts (Over 3,000 subjects recruited), plus multiple analysis projects. Focus on Appalachian families because these children are at very high risk for oral disease. CCDG Faculty involved: Marazita, Neiswanger, Vieira, Feingold, Shaffer

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