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SCR

Supplemental Data Figure 3A. S3. S3. WT. WT. SCR. SCR. S1. S1. -. -. CH-11. +. +. -. +. -. +. p-Stat-1. P-Stat1/actin ratio 0.91 0.92 0.95 0.98 0.94 0.94 0.94 0.92. Stat-1.

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SCR

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  1. Supplemental Data Figure 3A S3 S3 WT WT SCR SCR S1 S1 - - CH-11 + + - + - + p-Stat-1 P-Stat1/actin ratio 0.91 0.92 0.95 0.98 0.94 0.94 0.94 0.92 Stat-1 Stat1/actin ratio 0.95 0.95 0.95 0.97 0.97 0.97 0.96 0.96 b-actin Jak2 Jak2/actin ratio 1.32 0.95 1.06 0.98 0.67 0.47 0.90 0.99 Akt Akt/actin ratio 1.12 0.97 1.06 0.97 0.86 0.77 1.08 0.80 b-actin Expression of signaling proteins which have been shown to affect Fas trafficking in SBDS-knockdown and control cells. Cells were incubated with or without CH11 for 6 hours and protein expression was analyzed by western blotting (WT, Hela/WT; Scr, HeLa/shSCR; S-3, HeLa/shSBDS-3). Watanabe KI, Ambekar C, Wang H, Ciccolini A, Schimmer AD, Dror Y. SBDS-Deficiency Results in Specific Hypersensitivity to Fas Stimulation and Accumulation of Fas at the Plasma Membrane.

  2. Supplemental Data Figure 3B WT Scr S1 S3 Dyn 1/2 FAP1 -Actin PI3K β –actin Expression of signaling proteins which have been shown to affect Fas trafficking in SBDS-knockdown and control cells. Cells were incubated with or without CH11 for 6 hours and protein expression was analyzed by western blotting (WT, Hela/WT; Scr, HeLa/shSCR; S-3, HeLa/shSBDS-3). Watanabe KI, Ambekar C, Wang H, Ciccolini A, Schimmer AD, Dror Y. SBDS-Deficiency Results in Specific Hypersensitivity to Fas Stimulation and Accumulation of Fas at the Plasma Membrane.

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