Molecular Biology Primer. Angela Brooks, Raymond Brown, Calvin Chen, Mike Daly, Hoa Dinh, Erinn Hama, Robert Hinman, Julio Ng, Michael Sneddon, Hoa Troung, Jerry Wang, Che Fung Yung. Adapted from the above authors’ slides my Mark Fienup.
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Angela Brooks, Raymond Brown, Calvin Chen, Mike Daly, Hoa Dinh, Erinn Hama, Robert Hinman, Julio Ng, Michael Sneddon, Hoa Troung, Jerry Wang, Che Fung Yung
Adapted from the above authors’ slides my Mark Fienup
prokaryoticcells or eukaryotic cells.
plasma membrane forms
The genome of E.coli contains amount of t 4X106 base pairs
> 90% of DNA encode protein
Lacks a membrane-bound nucleus.
Circular DNA and supercoiled
Histones are unknown
The genome of yeast cells contains
1.35x107 base pairs
A small fraction of the total DNA encodes protein.
Many repeats of non-coding sequences
All chromosomes are contained in a membrane bound nucleus
DNA is divided between two or more chromosomes
A set of five histones
DNA packaging and gene expression regulationProkaryotic and Eukaryotic CellsChromosomal differences
(A cell is like a car factory that not only produces cars, but also car factors)
DNA’s structure is:
Lodish et al. Molecular Biology of the Cell (5th ed.). W.H. Freeman & Co., 2003.
DNA and RNA
can pair with
tRNA linear and 3D view:
Ribosome in Cytoplasm