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ncRNA. Jeremy Logue. The Expanding Repertoire of RNA. Adapted from Soares and Valcarcel (2006) EMBO. The Expanding World of Non-coding RNAs. Adapted from Huttenhofer, A et al. (2005) Trends in Genetics . HAR1-associated transcripts in genomic context.

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Presentation Transcript
ncrna

ncRNA

Jeremy Logue

slide2

The Expanding Repertoire of RNA

Adapted from Soares and Valcarcel (2006) EMBO

slide3

The Expanding World of Non-coding RNAs

Adapted from Huttenhofer, A et al. (2005) Trends in Genetics

slide5

HAR1-associated transcripts in genomic context

Of the 49 HARS identified (Human Accelerated Regions),

96% are in non-coding regions.

slide7

Expression of HAR1F and HAR1R in the developing neocortex

Cajal-Retzius cells establish early neuronal circuitry in the developing brain

slide9

What does this all mean?

Fill in the blank…

slide11

Dosage Compensation

Adapted from Straub and Becker (2007) Nature Reviews Genetics

slide12

Imprinted Versus Random X-inactivation

Adapted from Avnir and Heard (2001) Nature Reviews Genetics

slide13

The X-inactivation Center

Adapted from Avnir and Heard (2001) Nature Reviews Genetics

slide14

Xist Transcription in Embryonic Stem Cells

48 hrs.

Differentiation

Adapted from Avnir and Heard (2001) Nature Reviews Genetics

slide15

Potential Roles for Xist Antisense Transcription

Adapted from Avnir and Heard (2001) Nature Reviews Genetics

slide16

What does a silenced X look like?

Adapted from Chow, JC et al. (2005) Annu. Rev. Genomic Hum. Genet.

slide19

Problems Associated with Co-localization

Resolution = λ/(2NA)

z-axis problem

Figure 1G from Chaumeil, J. et al. (2007) Gen Dev

Calculating a cross-correlation can also aid in determining co-localization