The Secret Life of Vitamin A Holly Boettger-Tong, Wesleyan College Department of Biology. What is Vitamin A ?. Required for normal vision reproduction,differentiation, homeostasis Deficiency leads to blindness, sterility Retinol, Retinal, Retinoic acid all have biological activity.
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All-trans Retinoic acid
9-cis Retinoic acid
Retinoid binding protein
Receptor – binds
ligand and DNA,
All Trans Retinoic Acid
All trans RA
Levels of ATRA influence gene expression during development,
making ATRA a morphogen but also a potential teratogen.
% Failed Hatching
Dose of Retinoid (mM)
10nM 100nM 1mM
Effects of ATRA on Cardiogenesis and Vasculogenesis Development?