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Introduction

This workshop led by Michael S. Chapman from Oregon Health & Science University aims to engage participants in the fundamentals of biomolecular crystallography. Targeted at non-professional crystallographers, the workshop emphasizes crucial concepts such as mechanistic hypotheses, structural genomics, and the significance of rational design in research. Attendees will prepare for hands-on experiences and become intelligent collaborators in the field of crystallography. The session also includes recommended readings to support further exploration into this essential aspect of biomolecular research.

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Introduction

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  1. Introduction Lewis & Clark Workshops Michael S. Chapman (Oregon Health & Science University)

  2. Crystallography: substantial part of the Biomolecular Research Endeavor • Traditionally – Coat hanger: • Frame mechanistic hypotheses • Targets with established importance • Rational design – hypothesis-directed • Ligands, mutants... • Structural genomics • Discovery research • Induce function through homology • Structure more conserved than sequence Michael S. Chapman (Oregon Health & Science University)

  3. Workshop goals • Not professional crystallographer • Preparation for the 1st plunge • Intelligent collaborator • Critical user Michael S. Chapman (Oregon Health & Science University)

  4. Agenda Michael S. Chapman (Oregon Health & Science University)

  5. Introductory Texts • McPherson, A. (2003) (solid introduction) • Introduction to Macromolecular Crystallography, Wiley-Liss, Hoboken, NJ; 1st Ed., ISBN 0-471-25122-4 ($77.50) • Drenth, J. (1999) (more technical) • Principles of protein x-ray crystallography. New York, Springer, 2nd Ed., ISBN 0-387-98587-5 ($84.95) • Rhodes, G. (1993) (less technical) • Crystallography made Crystal Clear, Academic Press, ISBN 0-12-587075-2 Michael S. Chapman (Oregon Health & Science University)

  6. Next level • Biomolecular Crystallography • By Bernhard Rupp • ISBN 978-0-8153-4081-2 • Garland, in press October 2009; $145 • http://www.sb.fsu.edu/~chapman/Courses/Crystallography Michael S. Chapman (Oregon Health & Science University)

  7. Contact information • Lectures to be posted on: http://xtal.ohsu.edu/ • chapmami@ohsu.edu • (503) 494-1025 Michael S. Chapman (Oregon Health & Science University)

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