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APO E

APO E. Genetic Screening for Alzheimer’s and Metabolic Individuality. Apo E. Plays a critical role in transport of cholesterol and fats to the brain Insufficient fat and cholesterol in the brain play a critical role in AD

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APO E

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  1. APO E Genetic Screening for Alzheimer’s and Metabolic Individuality

  2. Apo E • Plays a critical role in transport of cholesterol and fats to the brain • Insufficient fat and cholesterol in the brain play a critical role in AD • Alzheimer’s patients have 1/6 of the concentration of free fatty acids in the CSF compared to other individulas • High fat diet increases cognitive function in AD patients

  3. APO E • The brain is 2% body mass but 25% totach cholesterol • Cholesterol needed to transmit nerve signals and fight infections • Apo E transports fats and choleserol • Apo E 4 is associated with increased risk • 20X increased risk when you have a 4/4

  4. Statins • Increased cholesterol in an APO E 4 may be the body trying to get more lipids to the brain by increasing synthesis • Statins • Sepsis, heart failure, fetal damage, and cancer • Cholesterol is so important to the brain that the astrocytes can make their own • Memory dysfunction • Reduce fatty acids and antioxidents to the brain • Reduce cell’s ability to synthesize coQ10 • Causes vitamin D deficiency

  5. APO E • Only apo in both csf and blood • Only certain cells can make it • Liver and brain • Astrocytes can usher lipids across the blood brain barrier using APO e

  6. Fats • Most cells can use either fats or glucose • The brain is unable to utilize fat for fuel • Fat protects the brain from oxidation • Oxygen causes oxidation • The body packages cholesterol according to where it is supposed to go • APO’s allow the package of cholesterol to enter the cell so that the fats can be utilized

  7. Apo E • APOE is associated with AD • APO E is the only APO in CSF and blood serum • Only certain types of cells can make it • Liver • Astrocytes in brain • Can usher lipids across blood brain barrier • It binds LDL, making it accessible to astrocytes as long as APO E is working • Convert fats in to the types that are more attractive the toe brain • The brain likes long chain fats

  8. Brain • Brain likes Omega 3 fats • Fats travel from liver to brain • Antioxidants protect them along the way

  9. Cholesterol and AD • Men with high cholesterol in their 50’s are susceptible to AD much later in life • High cholesterol is positively correlated with longevity in people over 85

  10. H Pylori • Possible correlation with H Pylori • More H Pylori in CSF in AD patients • 88% in AD • 47% of controls • 85% of treated patient had cognitive improvement in 2 years • C. Pneumoniae • 17/19 in AD • 1/19 in control group

  11. Ketogenic Diet • High fat • Low carb • Defective glucose metabolism in brain • Reduced beta amyloid • Reduce dependence on glucose • Improve the myelin sheath • High fat does not help people who are Apo E 4 positive

  12. Supplements • NADH • Consumes oxygen while converting pyruvate to lactate, reducing exposure of fats to oxygen • Significant cognitive decline in those who are predisposed to AD after oxygen exposure • Fatty acids • Antioxidants • Phospholipids • Avoid statins • Treat H pylori

  13. Stephanie Seneff • Apo E-R: The Clue to Why Low Fat Diet and Statins May Cause Alzheimer’s

  14. Exercise • Even if you are 80 or older, it is not too late • dancing • Reduce risk of developing dementia • Better cholesterol • Better blood flow • Better blood sugar • Less risk of depression

  15. Depression • Higher risk of dementia with depression • Omega 3 fatty acids

  16. Hormones • Hormone replacement therapy may reduce the progression and development of dementia / AD

  17. Learning • Focus on things that you are not good at • Numbers • Language • Art • Dancing

  18. Medications • Antidepressants • Antihistamines • Parkinson’s drugs • Anxiety meds • Seizure meds • Steroids • Blood pressure / heart meds

  19. weight • Obesity in middle age makes you twice as likely to develop AD

  20. Supplements • Fish oil • The brain is made of fat • Trans fats • Omega 3’s • Fish and plant fat

  21. Supplements • Ginkgo • Blood flow • Helpful in cardiovascular disease when the problem is a lack of blood flow to the head

  22. Supplements • heperzia • Choline • Carnitine

  23. Cholesterol and Sugar • 1/3 cup oat brain • 1 tbsp cinnamon • 1 tsp honey • ½ cup irish (steel cut) oatmeal

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