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FISIOLOGI PENYEMBUHAN LUKA. MOIST WOUND HEALING. George D Winter (1962): proved that wounds that were kept moist, healed better than those that were exposed to the air. THE FATHER OF MOIST WOUND HEALING. Home WORK : Why MOIST ?. Justifikasi.

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moist wound healing
MOIST WOUND HEALING
  • George D Winter (1962): proved that wounds that were kept moist, healed better than those that were exposed to the air.

THE FATHER OF MOIST

WOUND HEALING

Home WORK : Why MOIST ?

justifikasi
Justifikasi
  • Fibrinolisis : fibrin cepathilangpadasuasanalembab
  • olehnetrofildanselendotel
  • Angiogenesisi : prosesakanlebihterangsangpadasuasanalembab
  • Infeksi : lebihrendahdibandingkansuasanakering ( 2.6 % vs 7.1 % )
  • Percepatanpembentukanselaktif : invasinetrofi yang diikutiolehmakrophag, monositdanlimfositkedaerahlukaakanberfungsilebihdini.
  • Pembentukan growth factor : lebihcepatpadasuasanalembab * EGF, FGF dan Interleukin1 dikeluarkanolehmakrophaguntukproses angiogenesis danpembentukan str. Korneum * Platelet-derived Growth Factor (PDGF) dan Transforming Growth Factor-beta (TGF-beta) dibentukoleh platelet untukprosesproliferasi fibroblast.
types of wound healing
Types of Wound Healing
  • Healing by First Intention
  • Healing by Second Intention
  • Healing by Third Intention
inflammatory stage
Inflammatory Stage
  • Tanda : kemerahan, panas, nyeri dan bengkak
  • Last approximately 4 to 5 days
  • Permulaan terjadinya proses penyembuhan luka : aktifitas platelet untuk STOP perdarahan dan triggers the immune response
  • 24 jam pertama saat terjadi perlukaan, neutrophils, monocytes and macrophages mengontrol pertumbuhan bakteri dan membuang jaringan mati ( mempersiapkan dasar luka )
  • Characteristic red color and warmth is caused by the capillary blood system increasing circulation & laying foundation for epithelial growth
proliferation stage
Proliferation Stage
  • Begins within 24 hours of the initial injury and may continue for up to 21 days
  • It is characterized by three events:
    • Epithelialization
    • Granulation
    • Collagen synthesis
  • Formation of new capillaries that generate and feed new tissue
  • Granulation tissue is the beefy red tissue that bleeds easily
proliferation epitheliazation
Proliferation : Epitheliazation
  • Formation of an epithelial layer that seals and protects the wound from bacteria and fluid loss
  • It is essential to have a moist environment to foster growth of this layer
  • It is a very fragile layer that can be easily destroyed with aggressive wound irrigation or cleansing of the involved area
proliferation collagen synthesis
Proliferation : Collagen Synthesis
  • Creates a support matrix for the new tissue that provides it with its’ strength
  • Oxygen, iron, vitamin C, zinc, magnesium & protein are vital for collagen synthesis
  • This stage is the actual rebuilding and is influenced by the overall patient condition of the wound bed
maturation
Maturation
  • FINAL stage of wound healing
  • Begins around day 21 and may continue for up to 2 years
  • Collagen synthesis continues with eventual closure of the wound and increase in tensile strength
  • Tensile strength reaches only about 80% of pre-injury strength
refference
Refference
  • Idral Darwis.2008.Perawatan luka diabet.WOCARE publishing. Indonesia
  • Aida S.D. Suriadiredja.2007. History of wound healing and moist wound healing. Indonesian ETNEP paper.(not publication)
  • Carville Kerylin.1998. Wound care manual. Silver chain foundation.Australia
  • Bryant Ruth.2007. Acute and chronic wound. Mosby.USA