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p300
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PCAF. PCAF. Tat. Tat. Tat. Ac. Ac. Ac. Tat. 1. PCAF interacts with and acetylates Tat on lysine 28. 2. K28-acetylated Tat interacts with P-TEFb. P-TEFb. 3. P-TEFb/Tat complex binds TAR RNA. P-TEFb. 4. p300 acetylates Tat on lysine 50. RNA polymerase II. +1. p300. P.
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p300
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PCAF PCAF Tat Tat Tat Ac Ac Ac Tat 1. PCAF interacts with and acetylates Tat on lysine 28 2. K28-acetylated Tat interacts with P-TEFb P-TEFb 3. P-TEFb/Tat complex binds TAR RNA P-TEFb 4. p300 acetylates Tat on lysine 50 RNA polymerase II +1 p300 P 5. K50-acetylated Tat dissociates from TAR K50-acetylated Tat interacts with PCAF P P P P-TEFb P Tat Ac RNA polymerase II Ac +1
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