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Effects of PGB on IK Current Under Varying Conditions

This study investigates the impact of PGB (2.5 µM and 250 µM) on IK currents measured in nanoamperes (nA) at different voltages (-90 mV to +40 mV) over 30 ms durations. Control experiments were conducted with n=11 and n=10 to establish baseline responses. Results highlight significant variations in IK currents under different dosages of PGB, illustrating the compound's influence on ion channel activity. The data provide insights into potential pharmacological applications and mechanistic pathways affected by PGB.

louis-davidson
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Effects of PGB on IK Current Under Varying Conditions

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  1. 40mV PGB (2.5M) Ctrl Rec A B C -90mV 5nA 30ms IK (nA) 8 40mV PGB (250M) -90mV PGB (250M) 6 n=11 Control 4 Control 5nA mV 30ms -100 -80 -60 -40 -20 0 20 40 60 80 10 IK (nA) 8 40mV Control -90mV Control 6 n=10 PGB (250M) 4 PGB (250M) 2 5nA 30ms mV -100 -80 -60 -40 -20 0 20 40 60 80

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