Biotech & Pharma The Science, The Jobs, & Skills for Success Neil Stahl Ph.D. Regeneron Pharmaceuticals Overview Science at a Company vs. Academia Attributes for Success at a Company Biotech vs. Big Pharma Biotech : Innovation and Risk Drug Development 101
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Neil Stahl Ph.D.
1 Nature Biotechnology paper described 10% of KO’s ever made!
Less Successful Stories
Kd = 5 nM
Kd = 10 pM
Make T-shirts Tight-Binding “Traps”
Do Preclinical Work
File Investigational New Drug Application with FDA
File Biologics License ApplicationMaking a Proof of Concept into a Drug
Traditional: Tight-Binding “Traps” Random isolation of clones
FASTR : Isolation based on expression / characteristic of secreted protein
ELISASomething Old, Something NewWays to Isolate Over-Expressing Cell Lines
How to isolate clones after transfection:
IV & SC pharmacokinetics in Monkeys
Trap 10 mg/kg
Arthritis Severity Index
Trap 31 mg/kg
Research Post-Doctoral Scientist
Pharmaceutical Post-Doctoral Scientist