Structural analysis. “Molecular Dog” by Robert Chambers. From the bark of the Pacific yew tree (kills the tree to harvest enough); or a closely related compound from the needles of the European yew tree (doesn’t kill the tree).
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(What do you surmise the book was about?)
How many carbons in a row can you count in this molecule?____
Potential potent topoisomerase II inhibitor
Starting point: Molecule from oak-barrel-aged wine
(Change of stereochemistry = epimerization)
Prostratin (a molecule with potential to pull HIV out of hiding so it can be eliminated) can be synthesized from phorbol in several steps. What steps would be necessary to change the molecule phorbol into the molecule prostratin?
Phorbol: available from feedstock in quantity
Prostratin: found in a Samoan rainforest tree; not available from that source in sustainable quantity