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Bayesian Design Symposium: Enhancing Sarcoma Trials with Hierarchical Models

Join the Scientific Symposium opening session at CTOS featuring panelists George Demetri, MD, Scott Schuetze, MD, PhD, and Laurence Baker, DO as the moderator. Explore practical advantages of the Bayesian design showcasing user-friendly trial fronts facilitating data collection. Learn about planned studies on various sarcoma treatments like gemcitabine/docetaxel and Imatinib neoadjuvant treatment. Don't miss the dinner consensus discussion to delve deeper into improving sarcoma trials through innovative methodologies.

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Bayesian Design Symposium: Enhancing Sarcoma Trials with Hierarchical Models

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  1. Scientific Symposium • Opening session CTOS (1 pm to 5 pm) • CTOS reception (5pm to 6pm) • Dinner/Consensus Discussion (6pm to 9 pm) • Panel • George Demetri, MD • Scott Schuetze, MD, PhD • Laurence Baker, DO (moderator)

  2. P=Participating NP=Not Participating *Awaiting Contract **No longer accruing

  3. CR PR CR PR SD SD PD PD Month 2 Month 4

  4. PRACTICAL ADVANTAGES OF THE BAYESIAN DESIGN The hierarchical model allows data from each subtype to provide information about parameters in all other subtypes It avoids two undesirable approaches, conducting : - One trial, assuming one common parameter, ignoring the subtypes, or - Separate trials that ignore each others’ data User-friendly front ends greatly facilitate trial conduct

  5. 95% Posterior Credible Intervals by Histologic Subtype q = Pr( Response )

  6. 74 yo man with myofibroblastic sarcoma Pre-Gleevec H &. E 8 weeks on Rx cKIT

  7. 65 yo man with malignant fibrous histiocytoma Pre-Gleevec H & E 2 weeks on Rx cKIT

  8. Planned Studies • Gemcitabine/docetaxel in bone sarcomas • Imatinib neoaduvant treatment of DFSP • AMG 706 Phase II trial in sarcoma • BMS SRC inhibitor • Ziopharm active ifosphamide moiety • Uterine sarcoma adjuvant therapy

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