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Scientific Symposium

Scientific Symposium. Opening session CTOS (1 pm to 5 pm) CTOS reception (5pm to 6pm) Dinner/Consensus Discussion (6pm to 9 pm) Panel George Demetri, MD Scott Schuetze, MD, PhD Laurence Baker, DO (moderator). P=Participating NP=Not Participating *Awaiting Contract **No longer accruing.

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Scientific Symposium

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  1. Scientific Symposium • Opening session CTOS (1 pm to 5 pm) • CTOS reception (5pm to 6pm) • Dinner/Consensus Discussion (6pm to 9 pm) • Panel • George Demetri, MD • Scott Schuetze, MD, PhD • Laurence Baker, DO (moderator)

  2. P=Participating NP=Not Participating *Awaiting Contract **No longer accruing

  3. CR PR CR PR SD SD PD PD Month 2 Month 4

  4. PRACTICAL ADVANTAGES OF THE BAYESIAN DESIGN The hierarchical model allows data from each subtype to provide information about parameters in all other subtypes It avoids two undesirable approaches, conducting : - One trial, assuming one common parameter, ignoring the subtypes, or - Separate trials that ignore each others’ data User-friendly front ends greatly facilitate trial conduct

  5. 95% Posterior Credible Intervals by Histologic Subtype q = Pr( Response )

  6. 74 yo man with myofibroblastic sarcoma Pre-Gleevec H &. E 8 weeks on Rx cKIT

  7. 65 yo man with malignant fibrous histiocytoma Pre-Gleevec H & E 2 weeks on Rx cKIT

  8. Planned Studies • Gemcitabine/docetaxel in bone sarcomas • Imatinib neoaduvant treatment of DFSP • AMG 706 Phase II trial in sarcoma • BMS SRC inhibitor • Ziopharm active ifosphamide moiety • Uterine sarcoma adjuvant therapy

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