monogamous behavior in males n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Monogamous Behavior in Males PowerPoint Presentation
Download Presentation
Monogamous Behavior in Males

Loading in 2 Seconds...

play fullscreen
1 / 13

Monogamous Behavior in Males - PowerPoint PPT Presentation


  • 69 Views
  • Uploaded on

prarie vole pine vole california mouse common marmoset. montane vole meadow vole white-footed mouse rhesus monkey. Monogamous Behavior socially monogamous forms partner preference highly affiliative bi-parental. Non-Monogamous Behavior socially promiscuous

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

Monogamous Behavior in Males


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
monogamous behavior in males
prarie vole

pine vole

california mouse

common marmoset

montane vole

meadow vole

white-footed mouse

rhesus monkey

Monogamous Behavior

socially monogamous

forms partner preference

highly affiliative

bi-parental

Non-Monogamous Behavior

socially promiscuous

forms no partner preference

asocial

non-paternal

Monogamous Behavior in Males

HORMONAL, GENETIC, and NEURAL mechanisms

affiliative behavior test

Exp. Animal

Stranger

Partner

Exp. Animal

Stranger

Affiliative Behavior test

Partner Preference test

partner preference formation in prarie voles

Partner

Exp. Animal

Stranger

Partner preference formation in Prarie Voles

HORMONES

  • in males:
    • communication
    • sexual behavior
    • aggression
    • pair bonding

Role for Vasopressin (AVP)?

In voles (and humans) mating

stimulates AVP release

affiliative behavior

Exp. Animal

Stranger

Affiliative Behavior

prarie vole

montane vole

young et al, nature 1999

v1a receptor expression
V1a receptor expression

prarie vole

Ventral Pallidum has

higer V1a expression

montane vole

Lim et al, Nature 2004

v1a receptor gene
V1a receptor gene

GENETICS

--V1a receptor protein 99% homologous between vole species

--binding kinetics (affinity between hormone and receptor) identical

--expression level differences?

Young and Wang, Nature Neuroscience 2004

meadow vole role of v1a
Inject viral vector into specific brain areas

vector contains

lac Z gene (marker)

V1a receptor gene

Areas:

ventral pallidum

other areas

mate meadow vole

measure partner preference

Partner

Exp. Animal

Stranger

Meadow Vole: role of V1a

time with partner

time with stranger

Control injection

into VP

V1a Injection

into ventral pallidum

V1a Injection

into other brain areas

partner preference behavior

transgenics in non monogamous mice
Inject prarie vole V1a gene into mouse embryo

measure change in affiliative behavior after AVP injection as an adult

Exp. Animal

Stranger

Transgenics in non-monogamous mice
monogamous behavior in males1
prarie vole

pine vole

california mouse

common marmoset

montane vole

meadow vole

white-footed mouse

rhesus monkey

Non-Monogamous Behavior

socially promiscuous

forms no partner preference

non-paternal

Monogamous Behavior

socially monogamous

forms partner preference

bi-parental

Monogamous Behavior in Males

HORMONAL, GENETIC, and NEURAL mechanisms

HIGHER V1a expression

LOWER V1a expression

ventral pallidum
Ventral Pallidum

NEURAL

  • Part of the reward/reinforcement pathway
    • in lab rats:
      • cocaine use activates neurons in ventral pallidum
      • infuse psychostimulants directly into ventral pallidum
        • subjects develop ‘conditioned place preference’ for environment where injections occurred
  • Hypothesis in voles:
    • V1a in ventral pallidum: activation of this pathway during mating enhances choice of partner later
    • lack of V1a in non-monogamous voles results in no induction of reward pathway, no preference for partner later
summary
Summary

HORMONAL

  • Vasopressin (AVP) is involved in partner preference and affiliative behavior in monogamous voles
  • Differences in these behaviors between monogamous and non-monogamous species lies in the V1a receptor

GENETIC

  • monogamous voles have a different promoter that increases receptor expression in the ventral pallidum
  • induction of V1a receptor expression in non-monogamous species induces monogamous-like behaior

NEURAL

  • Ventral Pallidum appears to enhance partner preference because it activates the ‘reward pathway’ during mating
slide12

V1a viral vector insertion into Prarie vole ventral pallidum increases affiliative behavior

without the need for mating first.

insertion into caudate putamen doesn’t have this effect

# of receptors present

associated behavioral response

slide13

cerebrospinal fluid (vehicle)

V1a receptor antagonist

oxytocin receptor antagonist

cerebrospinal fluid

AVP

oxytocin

prarie vole with V1a receptor antagonist

before mating with female

after mating with female

Winslow et al Nature 1993