The use of human biospecimens in cancer research. Christopher A. Moskaluk M.D., Ph.D. University of Virginia. Cancers are made up of cells…. DNA RNA p roteins lipids. Which are made up of various molecules….
Christopher A. Moskaluk M.D., Ph.D.
University of Virginia
Which are made up of various molecules…..
Understanding the molecular and cellular basis of why cancer cells behave differently from normal cells makes up most cancer research efforts
A major source of cells and the biomolecules that make up those cells
Can be a source of cells, but mostly a source of biomarkers (molecules made by cells)
Isolate living cancer cells,
grow them in containers
Isolate living cancer tissue,
implant into special animals
In routine clinical practice, only materials left over from routine histologic examination of tissues usually are kept.
Embed representative pieces in wax blocks
Cut thin sections onto glass slides for microscopic examination
Fix in formaldehyde
Thrown away after a few weeks
Kept for years
These tissues are dead and are molecularly-damaged from the processing, hence are useful only for a limited range of studies.