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Stop TB Goals

Meeting of the Working Group on TB Drug Development Why you need to be engaged? Marcos Espinal Executive Secretary Stop TB Partnership 29 October 2004 Paris, France.

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Stop TB Goals

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  1. Meeting of the Working Group on TB Drug DevelopmentWhy you need to be engaged?Marcos EspinalExecutive SecretaryStop TB Partnership29 October 2004Paris, France

  2. I am pleased to let you know that… tuberculosis control has progressed to the point where virtual elimination of the disease as a public health problem appears to be within reach… So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you please go home, relax, and look for a more exciting job… November 1959, The Arden House Conference on Tuberculosis. New York The Arden House Conference on Tuberculosis. U.S. Department of Health, Education, and Welfare, Public Health Service No. 784. Washington, DC:US Government Printing Office; 1961.

  3. By 2005 70% Case detection under DOTS 85% Cure rate By 2015: Millennium Development Goals 50% reduction in prevalence and deaths by 2015 By 2050:The global incidence of TB disease will be less than 1 per million population New tools will take us there Stop TB Goals

  4. Challenges • Additional resources for health and poverty reduction • Workforce crisis: more & better human resources • Better harmonized and more effective aid • Strengthened health systems: primary care • Improved performance monitoring • Consolidate, sustain and advance achievements • Mobilise communities, the private sector, and enhance political commitment • Accelerate response to HIV/AIDS emergency • Invest in research & dev't to shape the future Source: 2nd Ad-hoc committee, September 2003

  5. Partnership towards Stop TB Targets Partners Forum TB/HIV WG DOTS Expansion WG Coordinating Board Secretariat/GDF TB Diagnostics WG DOTS-Plus MDRTB WG Goals & Targets New Vaccines WG New Drugs WG Communication/ Advocacy WG

  6. You need to deliver faster and affordable TB medicines Simplification / shortening TB treatment Improve latent TB treatment Effective against MDR-TB Be easily adoptable in the field WG Mission

  7. Why is important for the R & D community to keep engaged through the WG… Current tools are not sufficient and being away and isolated is not the solution MGIT …. About 15-20 years….

  8. Portfolio • Shared responsibility • Novartis donation to GDF – Eli Lilly discount to the GLC • Networking • Learning from others – duplication • Forum for a common agenda on new tools issues • economics, regulatory requirements, trial site register, immunological issues, market introduction, advocacy and communication • Get new tools into TB control in poor countries • Cross fertilization with other WGs • Global Plan to Stop TB

  9. The Global Plan to Stop TB (and 2003 update) • DOTS Expansion Working Group: 180 countries implementing DOTS • Working Group on TB/HIV: Policy for TB/HIV collaborative activies • Working Group on DOTS-Plus for MDR-TB: Treatment for MDR-TB in more than 10 countries • Working Group on New Diagnostics: Enabling environment for commercial tool development • Working Group on New TB Drugs: Pipeline of promising compounds • Working Group on New Vaccines: Two vaccine candidates entering phase I clinical trials

  10. Partnership Governance:Coordinating Board • High TB burden countries (4): China, India, Brazil, DR Congo • Regional representatives (6) • WHO, World Bank, UNAIDS, GFATM • Working Group Chairpersons (7) • Financial donors (4): CIDA, Japan, Euro (NL), USAID • Foundations (1): Gates Foundation • NGOs and technical agencies (3): IUATLD, CDC, IFRC • Communities affected by TB (1): Under selection • Chair of the WHO STAG: Mexico vice MOH • Corporate business sector: Heineken

  11. I am pleased to let you know that… tuberculosis control will progress to the point where elimination of the disease as a public health problem will be within reach… So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you please keep working hard because the quest is not yet over…

  12. Thank you… …for your contributions, and your continued collaboration in the Stop TB Partnership!

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