Rules of Inheritance. The rules of inheritance were unknown when Darwin developed the theory of natural selection The ‘hip’ idea at the time was the ‘ blending inheritance hypothesis ’. Rules of Inheritance.
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Natural selection operates on phenotypes of individuals (its immediate fitness), the effectiveness of selection in changing the composition of the population (and hence species) depends on the heritability of phenotypic characteristics
Genes themselves are perfect replicators, although sexual reproduction is imperfect
They also do not exist in isolation, but rather come as a ‘package deal’; consequently, they can only be selected for if they ‘get along’ with other genes and the entire package works as a whole (selection on the individual)