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Acetylcholinesterase (AChE)

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Acetylcholinesterase (AChE). Natalie, Kristin. Protein Synthesis. cychuang/files/cell1.jpg. Protein Structures. AChE.

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protein synthesis
Protein Synthesis

protein structures
Protein Structures



Breaks down acetylcholine, a neurotransmitter, into their ions which then allow many unconscious bodily functions to be performed

AChE catalyzes the reactions that are found where the nerves and muscles meet (neuromuscular junctions ) and in the brain

  •  Joel L. Sussman unveiled the structure in 1991 using X-rays
  • 537 amino acids long
  • Active site deep inside enzyme
    • Has two parts the anionic site and the esteratic site page 1

hydrolysis of acetylcholine ach
Hydrolysis of acetylcholine (ACh)
  • Once broken down into acetate and choline, those ions are then transmitted and functions can be performed, i.e. digestion, muscle movement, decision making, sexual arousal, salivation, and urination.
  • 25000 per second page 1

alzheimer s disease
Alzheimer’s occurs when concentration of ACh drop up to 90 %

Drugs are made to help lessen the effects of Alzheimer’s by inhibiting AChE

This allows for the concentration of ACh to increase slightly

Alzheimer’s Disease

AChE needs it’s specific shape that it gets from the DNA and RNA that code from it
  • Without that specific shape, the substrate, ACh, wouldn’t bond and wouldn’t have a way to be catalyzed which would make many vital functions in the human body stop

quiz time
Quiz Time!
  • What does AChE do?
  • Where is it located?
  • How many substrates are catalyzed per second?
  • How amino acids does AChE have?