Action Potential Types. Fast- and Slow Response Action Potentials. Slow response: Ionic currents. Why slow response?. High dv/dt: >200 V/s High conduction velocity: 1-4 m/s Specific drug sensitivity: sodium channel blockers – (lidocaine) and tetrodotoxin. Low dv/dt: < 20 V/s
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Why slow response?
High conduction velocity: 1-4 m/s
Specific drug sensitivity: sodium channel blockers –
(lidocaine) and tetrodotoxin
Low dv/dt: < 20 V/s
Low conduction velocity: 0.02-0.05 m/s
Specific drug sensitivity: calcium channel blockers –
Spontaneous phase 4 depolarizationFast response: Atria Slow response: Ventricles, Purkinje Fibers. SAN, AVN
SAN,AVN, Purkinje fibers
Membrane potential of SA nodal cells