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S-Adenosylmethionine (SAM) Is Generated from the S N 2 Reaction of Methionine and ATP

S-Adenosylmethionine (SAM) Is Generated from the S N 2 Reaction of Methionine and ATP. methionine. S -adenosylmethionine (SAM). Methionine adenosyl transferase. S N 2 reaction. adenosine triphosphate (ATP). Driving force for the reaction is subsequent hydrolysis of triphosphate.

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S-Adenosylmethionine (SAM) Is Generated from the S N 2 Reaction of Methionine and ATP

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  1. S-Adenosylmethionine (SAM) Is Generated from the SN2 Reaction of Methionine and ATP methionine S-adenosylmethionine (SAM) Methionine adenosyl transferase SN2 reaction adenosine triphosphate (ATP) Driving force for the reaction is subsequent hydrolysis of triphosphate

  2. S-Adenosylmethionine (SAM) Is A Biological Methylating Agent SAM-dependent methyl transferases SN2 reaction O-, S-, and N-Methylation N-methylation: DNA and tRNA bases, amine side chains in proteins O-methylation: protein carboxylates, polysaccharide alcohols, neurotransmitter phenols S-methylation: Thiols

  3. SAM at Work…

  4. Methylation of Norepinephrine to Epinephrine by SAM and PNMT Phenylethanolamine-N-methyl transferase (PNMT) norepinephrine Adrenal cortex Epinephrine (adrenalin) SAM

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