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TOXICOLOGY EDUCATION FACULTIES OF PHARMACEUTICAL SCIENCES PROF. W. LAMBERT GHENT UNIVERSITY (BE). OVERVIEW. END TERMS OF STUDY BaMa STRUCTURE & COURSES « TOXICOLOGY » COURSE OVERVIEW OF CHAPTERS PRACTICAL EXERCISES / EXAMs « ILLICIT DRUG » COURSE

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toxicology education faculties of pharmaceutical sciences prof w lambert ghent university be
TOXICOLOGY EDUCATIONFACULTIES OFPHARMACEUTICAL SCIENCESPROF. W. LAMBERTGHENT UNIVERSITY (BE)
overview
OVERVIEW
  • END TERMS OF STUDY
  • BaMa STRUCTURE & COURSES
  • « TOXICOLOGY » COURSE

OVERVIEW OF CHAPTERS

PRACTICAL EXERCISES / EXAMs

  • « ILLICIT DRUG » COURSE
  • « ENVIRONM. TOXICOL. » COURSE
  • POSTACADEMIC EDUCATION
  • SITUATION AT OTHER UNIVERSITIES
end terms of study
END TERMS OF STUDY
  • GENERAL & SOCIAL COMPETENCES

COMMUNICATION

CRITICAL INFORMATION ON MEDs

INSIGHT IN SOCIAL & ETHICAL ASPECTS OF PHARMACY

slide4
PHARMACEUTICAL KNOWLEDGE

BASIC SCIENTIFIC

PHARM / TECHNICAL

APPLICATION PHARM / MEDICAL SCIENCES TO PHARM PROBLEM

RATIONALIZED USE OF MEDs and PATIENT GUIDANCE

RELATION PATIENT – MEDICATION - PHARMACIST

KNOW / APPLY PHARMACOTHERAPY

slide5
KNOWLEDGE OF INTERACTIONS , INCOMPATIBILITIES & SIDE EFFECTS OF MEDs
  • KNOWLEDGE OF QUALITY MONITORING OF MEDs
bama structure 04 05
BaMa STRUCTURE ’04-’05

1st BACHELOR

2nd BACHELOR

3rd BACHELOR

BACHELOR OF SCIENCE

(Pharm. Sciences)

MASTER PROGRAM

1st bachelor
1st BACHELOR

ORGANIC CHEMISTRY 60 45

MATHEMATICS 22.5 30

PHYSICS 60 30

ANORG CHEMISTRY 60 45

ANATOMY & PHYSIOLOGY 45

ANIMAL BIOLOGY 30 22.5

PLANT BIOLOGY 30 15

DRUG DEVELOPM. & REPORT. 15 15

BASIC SCIENTIFIC KNOWLEDGE (80)

PHARMACEUTICAL KNOWLEDGE (20)

MEDICAL KNOWLEDGE

SCIENTIFIC LITERATURE & REPORTING

2nd bachelor
2nd BACHELOR

PHYTOCHEM & PHARMACOGNOSY 45 22.5

ANALYT. CHEM 45 120

PHARMACEUTICAL CHEM 30

BIOCHEM. & BIOPHYSICS 67.5 45

DISEASES 30

PHYSIOLOGY & PATHOPHYSIOLOGY 45 7.5

PHYSICOCHEM OF DRUGS 45 45

STATISTICS 15 30

PHARMACOKINETICS 22.5 7.5

BASIC SCIENTIFIC KNOWLEDGE (50)

PHARMACEUTICAL KNOWLEDGE (50)

MEDICAL KNOWLEDGE

SCIENTIFIC RESEARCH (PRACTICAL EXERCISES)

3rd bachelor
3rd BACHELOR

MEDICAL BIOCHEM 45 60

ANALYTICAL CHEM (INSTRUMENTAL) 45 75

PHARMACOLOGY 45

PHARMACOTHERAPY 15

PHARMACEUTICAL BIOTECHNOLOGY 45 15

MEDICINAL CHEMISTRY 45 15

PHARMACEUTICAL PREPARATIONS 45 60

PHARMACEUTICAL CASES 30

BASIC SCIENTIFIC KNOWLEDGE (20)

PHARMACEUTICAL KNOWLEDGE (80)

MEDICAL KNOWLEDGE

SCIENTIFIC RESEARCH & PRACTICAL EXERCISES

master program
MASTER PROGRAM

1st MASTER 1st MASTER

2nd MASTER 2nd MASTER

MASTER OF SCIENCE MASTER OF SCIENCE

PHARM. CARE DRUG DEVELOPMENT

PHARMACIST

PHARMACY SCIENT. CARREER

HOSPITAL PHARMACY INDUSTRIAL PHARM.

master pharmaceutical care
MASTER PHARMACEUTICAL CARE

« TRUNCUS COMMUNIS » WITH MASTER IN DRUG DEVELOPMENT

1st year 2nd year

MICROBIOLOGY 45:60 PHARM TECH 30:90

BROMATOLOGY 37.5:60 TOXICOLOGY 45:60

PHARMACOTHER 30:- PHARM DEONT 15:-

IMMUNOLOGY 10:- PHARM CARE & RAT.

THESIS USE OF MEDs 30:-

PRACTICE 6 M

pharmaco epidemiology 10 pharmaco economics 10
PHARMACO EPIDEMIOLOGY 10:-PHARMACO ECONOMICS 10:-

& FREE CHOICE OF 4 + 2 COURSES 10:- :

COMMUNICATION / PHARM INFORMATICS

URGENT MEDICAL ASSISTANCE /

MEDICAL DEVICES / PARASITOLOGY /

DIET PRODUCTS / ILLICIT DRUGS /

LAB. TESTS DIAGNOSIS / FOOD SECURITY

DERMOPHARMACY / COSMETOLOGY /

HOMEOPATHY / VETERINARY DRUGS

master drug development
MASTER DRUG DEVELOPMENT

« TRUNCUS COMMUNIS » WITH MASTER IN PHARM CARE

1st year 2nd year

MICROBIOLOGY 45:60 PHARM TECH 30:90

BROMATOLOGY 37.5:60 TOXICOLOGY 45:60

PHARMACOTHER 30:- PHARM DEONT 15:-

IMMUNOLOGY 10:- PHARM CARE & RAT.

THESIS USE OF MEDs 30:-

PRACTICE 6 M

advanced drug analysis 20 30
ADVANCED DRUG ANALYSIS 20:30

& FREE CHOICE OF 3 + 3 COURSES 10:- :

BIO-ANALYSIS / ADV. PHARM. BIOTECHNOL.

ENZYMOLOGY / DRUG DESIGN

MACROSCOP/MICROSCOP IMAGING

INTROD. CLIN. STUDIES / ADV. BIOPHARM.

MED LAB TECHNIQUES & IMMUNOCHEM

DRUG REGISTRATION / ENVIRONM TOX.

PHARMACOGENOMICS & PROTEOMICS

contact with toxicology
CONTACT WITH TOXICOLOGY
  • TOXICOLOGY 45/60

« TRUNCUS COMMUNIS » 2nd MASTER

  • ILLICIT DRUGS 10/-

FREE CHOICE (MASTER PHARM CARE)

  • ENVIRONMENTAL TOXICOL. 10/-

FREE CHOICE (MASTER DRUG DEVELOPMENT)

relation to end terms
RELATION TO END TERMS
  • PHARMACEUTICAL KNOWLEDGE

BASIC SCIENTIFIC

PHARM / TECHNOLOGICAL

  • KNOWLEDGE OF INTERACTIONS, INCOMPATIBILITIES & SIDE EFFECTS OF MEDs
  • KNOWLEDGE OF QUALITY MONITORING OF MEDICATIONS
toxicology course 45 60
TOXICOLOGY COURSE 45/60
  • DEFINITIONS

TOXICOLOGY

HUMAN TOXICOLOGY

FORENSIC

CLINICAL

OCCUPATIONAL

ENVIRONMENTAL

2 analytical toxicol techniques
2. ANALYTICAL TOXICOL. TECHNIQUES

SAMPLE PREP : LLE SPE

SCREENING : EMIT

CHROMATOGRAPHY : TLC

HPLC - DAD/MS GC - MS/NPD

HEAD-SPACE GC

RELEVANT IN LATER PARTS

3 toxic efffects time location type
3. TOXIC EFFFECTS TIME / LOCATION / TYPE
  • LOCAL – SYSTEMIC

ACUTE – CHRONIC

LATENT

TEMPORARY – PERMANENT – CUMULATIVE

  • INFLAMMATION NECROSIS

ENZYME INHIBITION

LETHAL INCORPORATION

LIPID PEROXIDATION

slide20
COVALENT BINDING

RECEPTOR INTERACTION

HYPERSENSITIVITY

IMMUNE SUPPRESSION

CARCINOGENIC EFFECTS

FOETOTOXICITY

RELEVANT TOXICOLOGICAL DEFINITIONS

4 dose response curve
4. DOSE – RESPONSE CURVE

DEFINITIONS & INTERPRETATION

PARAMETERS

THERAPEUTIC INDEX

MARGIN OF SAFETY

ACUTE LETHAL TOXICITY

EFFICACY

DERIVATION OF PROBIT DIAGRAM

5 toxicokinetics
5. TOXICOKINETICS

OVERDOSE PHARMACOKINETICS

ABSORPTION DISTRIBUTION

METABOLISM ELIMINATION ADME

CLINICAL IMPLICATIONS IN OVERDOSE CASES

6 biotransformation
6. BIOTRANSFORMATION

PHASE – I – REACTIONS

OXIDATION REDUCTION

HYDROLYSIS

EPOXIDE HYDROLYSIS

PHASE – II – REACTIONS

CONJUGATION

ACETYLATION

METHYLATION

7 bioactivation examples
7. BIOACTIVATION EXAMPLES

ACETAMINOPHEN METHANOL

CARBON TETRACHLORIDE

BROMOBENZENE ISONIAZIDE*

AROMATIC AMINES

HALO ALKANES

DIFFERENT MECHANISMS

*GENETIC POLYMORPHISM

ENZYME TRANSPORTER TARGET

8 authentic forensic cases
8. AUTHENTIC FORENSIC CASES

FATALITY BY CYP3A4 INHIBITION

KETOCONAZOLE / TERFENADINE

INTOXICATION BY SODIUM AZIDE

INTERACTIONS

CAPABILITIES & LIMITATIONS OF

CHROMATOGR / SPECTROM TECHN

9 medications and illicit drugs
9. MEDICATIONS AND ILLICIT DRUGS

PSYCHOLEPTICS

PSYCHOANALEPTICS

PSYCHODYSLEPTICS

FOR EACH INDIVIDUAL COMPOUND

WHAT ; ADME ; PHARMACODYNAMICS ;

EFFECTS ; RISKS ; TREATMENT IN OVERDOSES ; ANALYTICAL ASPECTS

a psycholeptics
a) PSYCHOLEPTICS
  • ETHANOL

+ ANALYTICAL ASPECTS

  • BARBITURATES
  • OPIATES

MORPHINE - HEROINE

PETHIDINE

METHADON - BUPRENORPHINE

+ EFFECT ON NEUROTRANSMISSION

+ TREATMENT ADDICTION / OVERDOSE

slide28
HYPNOTICS / SEDATIVES

METHAQUALONE MEPROBAMATE

BENZODIAZEPINES

+ MECHANISM AT RECEPTOR

+ GABA

+ FLUMAZENIL

slide29
SOLVENTS

ABUSED SOLVENTS

SOLVENTS IN WORKING PLACE

BENZENE

TOLUENE

CARBON DISULFIDE

HEXANE

+ BIOMARKERS OF EXPOSURE

b psychoanaleptics
b) PSYCHOANALEPTICS
  • COCAINE

+ TREATMENT OF ADDICTION

CATALYTIC AB

PARTIAL AGONISTS

  • AMPHETAMINES
  • MDMA & ANALOGS (MDEA PMA MTA)
  • NICOTINE
  • CAFEINE (EU/BE GUIDELINES)
  • KHAT
c psychodysleptics
c) PSYCHODYSLEPTICS
  • CANNABINOIDS
  • LSD
  • TRYPTAMINES

SAME ASPECTS AS ABOVE

10 carbon monoxide
10. CARBON MONOXIDE

SOURCES KINETICS

EFFECTS ANALYTICAL ASPECTS

TREATMENT OF INTOXICATION

11. CYANIDES

SOURCES KINETICS

EFFECTS ANALYTICAL ASPECTS

TREATMENT OF INTOXICATION

12 pesticides
12. PESTICIDES
  • ORGANOPHOSPHATES

+ MECHANISM OF ACTION / EFFECTS

+ TREATMENT

  • CARBAMATES
  • ORGANOCHLORINE DERIVATES
  • PYRETHRUM INSECTICIDES
  • HERBICIDES 2,4-D 2,4,5-T MCPA
  • PARAQUAT - DIQUAT

+ MECHANISM TOXICITY /TREATMENT

practical exercises
PRACTICAL EXERCISES
  • QUANTITATION OF ETHANOL
  • EXTRACTION OF DRUGS / MEDs

LLE / SPE

  • TLC OF DRUGS / MEDs
  • IDENTIFICATION UNKNOWN DRUGS
  • DEMONSTRATIONS

EMIT / AAS / HPLC GC - MS / CO

  • PRESENTATION BY FED. POLICE

ILLICIT DRUGS

examination
EXAMINATION
  • PRACTICAL EXERCISES

PERMANENT (ORAL)

AT THE END (BY WRITING)

  • THEORY

AT THE END (BY WRITING)

  • RATIO IN FINAL QUOTATION 4 / 16
illicit drugs course 10 free choice master pharm care
ILLICIT DRUGS COURSE 10/-FREE CHOICE MASTER PHARM CARE
  • DEFINITIONS

NEURONAL & SYNAPTIC TRANSM.

AGONIST / ANTAGONIST

  • RELEVANT GROUPS

OPIATES ; ANTIDEPRESSANTS

STIMULANTS ; PSYCHEDELICS

CANNABINOIDS ; SMART DRUGS

  • EXAMINATION

AT THE END ( BY WRITING )

environm tox course 10 free choice master drug devel
ENVIRONM. TOX. COURSE 10/- FREE CHOICE MASTER DRUG DEVEL.
  • DEFINITIONS

ENVIRONM CHEM / TOXICOLOGY

ECOTOXICOLOGY

BIOACCUMULATION

  • SPECIFIC GROUPS

VOC’s PAH’s PCB’s

  • EXAMINATION

AT THE END ( BY WRITING )

postacademic course for judicial experts ugent
POSTACADEMIC COURSE FOR JUDICIAL EXPERTS (UGent)
  • TYPES OF EXPERTISES
  • PROCEDURES BY EXPERTISES
  • DEONTOLOGY
  • CRIMINAL LAW
  • INSURANCE LAW
  • SOCIAL LAW
  • COURSES OF 3 HOURS

START ’99 – ’00 (180 stud) ; ’01 – ’02 (100)

additional technical education for judicial experts
ADDITIONAL TECHNICAL EDUCATION FOR JUDICIAL EXPERTS
  • VETERINARY EXPERTISES
  • FORENSIC & DNA EXPERTISES
  • ECOLOGICAL EXPERTISES
program at kul leuven
PROGRAM AT KUL (LEUVEN)

BaMa PHARMACEUTICAL CARE

DRUG DEVELOPMENT

  • TOXICOLOGY I (40 h, TRUNC. COMM.)

CONTENT SIMILAR AS UGent

  • TOXICOLOGY II (15 h, FREE CHOICE)

TOXICITY OF INDUSTRIAL PRODUCTS

  • TOX. OF FYTOPHARMACEUT. PRODUCTS

(15 h, FREE CHOICE)

postacademic course multidisciplinary forensic research kul
POSTACADEMIC COURSE MULTIDISCIPLINARY FORENSIC RESEARCH (KUL)
  • SESSIONS OF 3 h
  • BALLISTICS
  • FIRE & EXPLOSION FORENSICS
  • FORENSIC ACCOUNTANCY
  • CHILD ABUSE
  • DNA FORENSICS
  • TRAFFIC ACCIDENTS
  • FORENSIC TOXICOLOGY
program at ua antwerp
PROGRAM AT UA (ANTWERP)
  • TOXICOLOGY COURSE 45 h, 4th year

SIMILAR CONTENT TO UGent

LITTLE INFORMATION AVAILABLE

NO POSTACADEMIC COURSE IN TOX.

program at vub brussels
PROGRAM AT VUB (BRUSSELS)
  • TOXICOLOGY 45 h, 4th year

PRACTICAL EXCERCISES 105 h

  • TOXICITY OF COSMETICS 15 h, 5th y.

NO POSTCADEMIC COURSE IN TOX.

conclusion
CONCLUSION
  • BaMa PROGRAM

SUFFICIENT TOXICOLOGICAL EDUCATION PROVIDED

  • POSTACADEMIC EDUCATION

AT UgENT (yearly)

AT KULeuven (yearly)

PROBLEM : TARGET GROUP HAS IN MOST CASES ALREADY SEVERAL YEARS OF EXPERTISE