LIMBIC SYSTEM. History. Paul Broca (1824-1880): 1878: “ le grand lobe limbique ” Refers to a ring of gray matter on the medial aspect of the cerebral hemispheres. James Papez (1883-1958):
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1878: “le grand lobe limbique”
Refers to a ring of gray matter on the medial aspect of the cerebral hemispheres.
1930’s: defined a limbic system that might underlie the relationship between emotion and memory (Papez’ circuit).
Emotional and motivational aspects of behavior.
Provides emotional component to learning process:
Especially the amygdala.
Especially the hippocampus.
Brainstem reticular formation
Provides direct input to basal ganglia and motor system.
Related to olfactory cortex.
Connected to hypothalamus.
(associated with visual,
auditory, tactile senses)
Brainstem (viscerosensory relay
Nuclei: solitary nucleus
and parbrachial nucleus)
Dorsal Medial Thalamic Nucleus
Feeding and drinking
Agnostic (fighting) behavior
Mating and maternal care
Responses to physical or emotional stresses.
Anterior Cingulate Gyrus
Orbitofrontal Areas (10, 11)
Medial and lateral temporal lobe
Entorhinal cortex (24)
Ventral Anterior Nucleus
Medial Globus Pallidus
Other hypothalamic nuclei
(Basal nucleus of Meynert)
and dentate gyrus)
Cortex of Cingulate Gyrus
Loss of normal fear/anger response
Damage to hippocampus portion:
Cells undergoing calcium-induced changes associated with memory
Increase in sexual activity.
Compulsive tendency to place objects in mouth.
Changes in eating behavior.